Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Long-term metastatic cancer survivorship rises sharply in the Netherlands

Dutch registry data show a steep rise in people living years with de novo metastatic incurable cancer, led by prostate, lung, and breast tumors.

LAIR1 on glioma-associated macrophages drives immune suppression, weakens phagocytosis, and is linked to poorer survival and anti-PD-1 resistance.

Hypoxia-driven HMGB1 was linked to aggressive oral squamous cell carcinoma, worse survival, and activation of NLRP3-caspase-1 signaling.

COMPASS 2.0 examines real-world comparative effectiveness of nab-paclitaxel versus standard chemotherapy in platinum-resistant ovarian cancer.

PSA remains central after prostate cancer diagnosis, helping detect biochemical recurrence, guide imaging, and measure response to advanced…

Prostate cancer treatment can trigger distress over sexuality, body image, and self-esteem, making early counseling and support essential.

Pancreatic cancer cells drive muscle atrophy through lactate-induced redox stress, lowering NAD+ and α-ketoglutarate in myotubes and mouse…

Fudan University is launching a phase 2 trial of retlirafusp alfa, zeprumetostat, apatinib, and CAPOX for first-line metastatic…

Adults after autologous stem cell transplant appraised symptom clusters during neutropenia through trajectories that drove when they reported…

Nature Reviews Clinical Oncology reviews exercise oncology evidence, finding survival benefit in colon cancer but mixed results across…

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds