Critical Care

Trials, guidelines and clinical evidence across Critical Care.

Federated Learning Preserves SHAP Explainability in ICU Mortality Models

SHAP rankings stayed moderately to strongly aligned between centralized and federated ICU mortality models, with AUROC near centralized performance.

By Dr. Aishwarya N., MBBS · 4 hrs ago · 5 min read

Critical Care·BMJ Open

Viscoelastic Assay-Guided Transfusion in ICU Bleeding: Meta-Analysis Protocol

BMJ Open protocol outlines a systematic review of viscoelastic haemostatic assay-guided transfusion versus conventional testing in bleeding critically…

3 days ago

Critical Care·DailyMed

Vasopressin in Sodium Chloride Injection Label Expands ICU Use

DailyMed updates vasopressin in sodium chloride injection for vasodilatory shock, with dosing, warnings, interactions, and ICU safety limits.

4 days ago

Critical Care·DailyMed

Normosol-R and 5% Dextrose Label Updates Detail Fluid Replacement Uses

Updated DailyMed labeling for Normosol-R and 5% Dextrose defines balanced electrolyte replacement, key warnings, and monitoring needs in…

4 days ago

Critical Care·ClinicalTrials

Weighted Blankets for ICU Agitation Enter Randomized Trial at AnMed

AnMed’s HARMONIA trial will test whether weighted blankets reduce ICU agitation, with RASS change at 1 hour as…

5 days ago

Critical Care·Sci Transl Med

Oxford Nanopore Sequencing Could Speed ICU Infection Diagnosis

A narrative review examines Oxford Nanopore sequencing in ICU care, where rapid pathogen identification and resistance profiling may…

6 days ago

Critical Care·Nature

Endothelial markers track DIC progression in sepsis, study finds

In 324 septic patients, endothelial injury markers tracked DIC progression and 28-day mortality, with syndecan-1 and angiopoietin-2 most…

6 days ago

Critical Care·medRxiv

Vasopressin in Septic Shock Linked to Higher Costs, GOSSIS Calibrates Well

In septic shock, vasopressin use was tied to higher adjusted hospital costs, while GOSSIS closely matched observed ICU…

7 days ago

Critical Care·Nature

Lactate-to-albumin ratio tracks mortality risk in critically ill adults

Serial lactate-to-albumin ratio measurements predicted mortality in ICU patients, but added little beyond lactate and lacked a universal…

Nov 5, 2026

Critical Care·medRxiv

Pantoprazole protocol targets dialysis subgroup in REVISE secondary analysis

A planned REVISE secondary analysis will test whether dialysis status alters pantoprazole’s effect on upper GI bleeding and…

Nov 5, 2026

Critical Care

Trials, guidelines and clinical evidence across Critical Care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.