Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Glioma ontogeny model reframes neuroepithelial tumor therapy

A JCO review proposes that gliomas recapitulate brain development and argues for anatomy-guided multimodal treatment planning.

A JCO comparative effectiveness trial found mindfulness and Tai Chi improved fatigue and pain after cancer treatment, with…

Five-year ASCOT follow-up shows adjuvant S-1 improved overall survival after resected biliary tract cancer, with durable benefit across…

Personalized ctDNA detected most localized sarcomas and tracked response to radiotherapy and pembrolizumab while predicting survival in SU2C-SARC032.

Immune checkpoint inhibitor toxicity varies across patient groups, but limited trial diversity leaves major gaps in understanding race-related…

In 216 patients with cervical cancer, symptom burden rose with anxiety and depression, while psychological flexibility appeared protective…

Authors reply to comparator concerns in NSCLC trials, clarifying that OptiTROP-Lung05 was not built to prove superiority over…

A review outlines integrated CAR-T engineering for solid tumours, from logic-gated activation and metabolic tuning to TME remodeling…

Cell Press reports that MCUB limits mitochondrial calcium in glioblastoma, a mechanism tied to metabolic adaptation and tumor…

A systematic review examines NSUN2-driven m5C RNA methylation and its roles in cancer, cardiovascular, neurologic, infectious, and metabolic…

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds