Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Cutaneous Leiomyosarcoma Extension Linked to Higher Recurrence Risk

Retrospective cohort data show subcutaneous extension in cutaneous leiomyosarcoma was tied to higher recurrence and inconsistent imaging surveillance.

By Dr. Revathy Mohan V.R., MBBS · Oct 19, 2026 · 5 min read

Oncology·Brain

Vebreltinib Case Report Shows Durable Response in MET-Amplified Cholangiocarcinoma

A case report describes durable response to vebreltinib in heavily pretreated MET-amplified intrahepatic cholangiocarcinoma, supporting biomarker-driven treatment.

Oct 19, 2026

Oncology·Cancer Disc

ARID2 Loss Alters Kynurenine-AhR Signaling in CTNNB1-Mutant HCC

AACR research links ARID2 loss to kynurenine-AhR pathway rewiring in CTNNB1-mutant hepatocellular carcinoma, with implications for antitumor immunity.

Oct 19, 2026

Oncology·Cancer Disc

Serplulimab, radiotherapy and chemotherapy enter phase II pancreatic cancer testing

A phase II multicenter trial tests serplulimab with radiotherapy and chemotherapy as first-line therapy for metastatic pancreatic adenocarcinoma.

Oct 19, 2026

Oncology·Gut

Cambodia liver cancer burden rises as viral and metabolic causes shift

Cambodia’s hepatocellular carcinoma burden rose from 1990 to 2021, with viral hepatitis still dominant and metabolic and alcohol-related…

Oct 19, 2026

Oncology·PubMed

Natural Killer Cells Target Chronic Myelogenous Leukemia via Direct Killing and ADCC

NK cells altered K562 chronic myelogenous leukemia behavior and killed stem-like cells directly, while differentiated cells remained vulnerable…

Oct 19, 2026

Oncology·BMJ

Endometrial cancer patients report major information gaps at diagnosis and treatment

Women diagnosed with endometrial cancer reported substantial unmet information needs before diagnosis, at diagnosis, and during treatment.

Oct 19, 2026

Oncology·Lancet

Photobiomodulation reduced trismus pain during head and neck radiotherapy

A randomized triple-blind trial found photobiomodulation reduced trismus-related pain during head and neck radiotherapy, though mouth opening was…

Oct 19, 2026

Oncology·Br J Cancer

Macrophage Marker sCD163 Predicts Worse mCRPC Outcomes

Serum sCD163 and sSIRPα were higher in metastatic prostate cancer, and sCD163 predicted shorter progression-free survival in mCRPC.

Oct 19, 2026

Oncology·Br J Cancer

Spatial Transcriptomics Reveals Immunosuppressive Niches in Colorectal Cancer

Spatial and single-cell transcriptomics mapped IFI6+ Tregs and SPP1+ macrophages in colorectal cancer, exposing new immune-evasion pathways.

Oct 19, 2026

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.