Rheumatology

Trials, guidelines and clinical evidence across Rheumatology.

CD19 CAR T Therapy Reshapes Gut Microbiota Immunity in Autoimmune Disease

Longitudinal profiling in 20 autoimmune patients found CD19 CAR T therapy altered gut IgA/IgG responses, microbiota composition, and relapse-linked signals.

By Dr. A. Nikhil Krishnan, MBBS · 1 min ago · 5 min read

Rheumatology·STAT

Biogen’s lupus readout puts litifilimab and strategy to the test

Biogen’s upcoming Phase 3 lupus readout for litifilimab will test both the drug and CEO Chris Viehbacher’s R&D…

6 hrs ago

Rheumatology·ARD

ANCA Vasculitis Guidelines Need Stronger Patient Input and Implementation

A critical appraisal of 11 ANCA-associated vasculitis guidelines found wide variation, weak patient involvement, and poor implementation planning.

7 hrs ago

Rheumatology·ARD

Systemic sclerosis: Triple autoantibody-negative patients show more myopathy

In the SPRING registry, nearly 1 in 5 patients with systemic sclerosis lacked ATA, ACA, and RNAP3 and…

7 hrs ago

Rheumatology·ARD

End-stage knee osteoarthritis lacks a consistent clinical definition, review finds

A scoping and narrative review finds end-stage knee osteoarthritis is used inconsistently, often as shorthand for surgery eligibility…

7 hrs ago

Rheumatology·ARD

Anifrolumab trial post-hoc analysis ties LLDAS to SLE response

Post-hoc analysis of the phase IIb MUSE trial examined whether LLDAS attainment could identify responders in systemic lupus…

15 hrs ago

Rheumatology·ARD

Pregnancy Care in Rheumatic Disease Hinges on Remission and Risk Stratification

A 2025 review outlines pregnancy risks in autoimmune rheumatic disease, emphasizing remission before conception, compatible therapies, and multidisciplinary…

15 hrs ago

Rheumatology·ARD