Pain Medicine

Clinical evidence, research, and medical intelligence in Pain Medicine.

Oxycodone Label Update Tightens Warnings on Overdose and Respiratory Risk

DailyMed’s updated oxycodone label reinforces lowest-dose prescribing, overdose counseling, respiratory depression risk, and drug interaction warnings.

By Dr. A. Nikhil Krishnan, MBBS · 2 days ago · 5 min read

Pain Medicine·DailyMed

Oxycodone/Acetaminophen Label Warns of Overdose, Respiratory Depression

DailyMed’s updated label for oxycodone and acetaminophen details boxed warnings, dose-related respiratory depression, drug interactions, and hepatotoxicity.

3 days ago

Pain Medicine·DailyMed

Topical Lidocaine and Menthol Gel Label Clarifies OTC Pain Use

DailyMed label for an OTC lidocaine and menthol roll-on defines temporary pain relief, age limits, and key safety…

6 days ago

Pain Medicine·JNCI

Sleep and Chronic Pain Across the Lifespan: A Review of Shared Mechanisms

A narrative review links sleep disturbance with chronic pain from childhood through older age, with shared biology and…

Nov 4, 2026

Pain Medicine·JAMA

Acute Low Back Pain Treatment Linked to OUD and Overdose Risk

In Medicaid patients with acute low back pain, opioids and gabapentinoids were tied to higher OUD or overdose…

Oct 25, 2026

Pain Medicine·ClinicalTrials

Cebranopadol Phase 2 Trial Targets Opioid Withdrawal in Chronic Pain

Phase 2 trial tests cebranopadol against placebo for opioid withdrawal symptoms in adults with chronic pain and physical…

Oct 24, 2026

Pain Medicine·Nature

Chronic pain review links central sensitization measures to poorer procedure outcomes

A 24-study meta-analysis found higher CSI scores and temporal summation were linked to greater pain after invasive peripheral…

Oct 24, 2026

Pain Medicine·STAT

Peripheral Nerve Stimulation Guidelines Expand Chronic Pain Treatment

ASPN consensus guidelines update peripheral nerve stimulation evidence and clinical use across chronic pain and neurologic indications, with…

Oct 23, 2026

Pain Medicine·BMJ Open

Acupuncture Trial Targets Acute Neck Pain From Stiff Neck

A pilot randomized trial will test Houxi (SI3) acupuncture for acute stiff-neck pain, with NPQ and McGill pain…

Oct 22, 2026

Pain Medicine·ClinicalTrials

Trigger Point Injection Trial Tests Focused vs Multi-Target Neck Pain Care

A randomized trial will compare focused versus multi-target lidocaine trigger point injections for chronic myofascial neck pain under…

Oct 22, 2026

Pain Medicine

Clinical evidence, research, and medical intelligence in Pain Medicine.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.