Hematology

Trials, guidelines and clinical evidence across Hematology.

Uganda study finds high antifolate resistance in children with sickle cell anaemia

Molecular analysis in Ugandan children with sickle cell anaemia found widespread SP resistance markers and emerging higher-level antifolate haplotypes.

By Dr. Revathy Mohan V.R., MBBS · 1 min ago · 5 min read

Hematology·JACC

ASFA Updates Therapeutic Apheresis Guidelines With 183 Indications

ASFA’s tenth evidence-based apheresis update spans 93 fact sheets and 183 graded indications across a wide range of…

11 hrs ago

Hematology·ClinicalTrials

Azithromycin Added to Prednisone in Pediatric ITP Trial

A randomized pilot trial tested azithromycin plus prednisone in children with newly diagnosed immune thrombocytopenia, with platelet and…

2 days ago

Hematology·CMAJ

Iron-deficiency anemia care barriers persist for women in Alberta

Alberta clinicians described knowledge gaps, system constraints, and inequities that complicate iron-deficiency anemia care in reproductive-aged women.

2 days ago

Hematology·ACC-PRO

Beam sickle cell therapy data position risto-cel against Casgevy, Lyfgenia

Beam’s base-edited sickle cell therapy kept 31 patients free of vaso-occlusive crises for 12 months, setting up a…

2 days ago

Hematology·Nat Rev Onc

St. Jude Opens Sickle Cell Disease Clinical MD Fellow Position

St. Jude is recruiting a one-year clinical MD fellow to train physicians in pediatric sickle cell disease, hemophilia,…

3 days ago

Hematology·Cancer Cell

Bone Marrow Megakaryocytes Present Antigen and Activate CD4 T Cells

Cancer Cell abstract describes MHC II-expressing bone marrow megakaryocytes as noncanonical antigen-presenting cells capable of activating CD4 T…

3 days ago

Hematology·JCI

CD48-CD244 Axis Linked to NK Cell Dysfunction in Multiple Myeloma

Multiomic profiling links CD48 signaling to shifting NK cell activity, exhaustion, and myeloma progression, pointing to a context-dependent…

3 days ago

Hematology·JCI

Castleman disease linked to vascular smooth muscle cell abundance in lymph nodes

Single-cell and spatial profiling identified vascular smooth muscle cell abundance as a stromal hallmark of unicentric Castleman disease…

3 days ago

Hematology·DailyMed

Phytonadione tablets update clarifies vitamin K dosing and INR response

DailyMed’s updated phytonadione label details adult dosing, INR timing, absorption limits, contraindications, and key bleeding safety cautions.

3 days ago

Hematology

Trials, guidelines and clinical evidence across Hematology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.