Genetic And Genomic Medicine

Clinical evidence, research, and medical intelligence in Genetic And Genomic Medicine.

Shelterin loss of function linked to lipoma and uterine leiomyoma

Population-scale exome analysis links germline shelterin loss of function to lipoma and uterine leiomyoma, with signals for long-telomere cancer risk.

By Dr. A. Nikhil Krishnan, MBBS · 7 days ago · 5 min read

Genetic And Genomic Medicine·medRxiv

Long-read genomes reveal selection-linked loci in African-ancestry cohort

Long-read and short-read genomes from All of Us identified selection-enriched loci and structural variants in a Black or…

Nov 5, 2026

Genetic And Genomic Medicine·medRxiv

Variant-Effect Predictions Map Trait-Specific Heritability Layers

Predicted variant effects linked complex-trait heritability to different regulatory layers, with distinct signals across height, brain traits, and…

Oct 27, 2026

Genetic And Genomic Medicine·medRxiv

Phosphoproteome GWAS maps genetic control of protein phosphorylation in humans

A first-of-its-kind phosphoproteome GWAS links genetic variants to site-specific phosphorylation, revealing disease-relevant signaling not seen in protein abundance.

Oct 27, 2026

Genetic And Genomic Medicine

Clinical evidence, research, and medical intelligence in Genetic And Genomic Medicine.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.