Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

HPV Oncogenes Create PRIMPOL-Dependent Weakness in HNSCC

HPV oncogenes alter DNA crosslink repair in head and neck cancer, exposing PRIMPOL- and RAD51-dependent vulnerabilities during cisplatin treatment.

CDKN2A/p16 loss reshaped Golgi morphology in melanoma cells and created a lipid peroxidation vulnerability that could be therapeutically…

Low light power density preserved singlet oxygen generation and tumor perfusion in photodynamic therapy, suppressing distant tumors better…

A preprint identifies a transferable SOX9 C-terminal module that recruits cBAF, opens enhancers, and preserves stem-like cell state…

A zebrafish atlas paired with computational analysis maps organ-specific cancer dissemination and reveals heterogeneous metastatic behavior in Ewing…

New BRCA1 saturation genome editing data across cell types improve classification of rare variants and reveal hypomorphic alleles…

VRMOD predicts cis-regulatory sequences from DNA alone across 309 vertebrate genomes, with validation at the FTO locus and…

Transcriptomic network analysis identified breast cancer hub genes and ranked niclosamide as the top repositioned candidate after in…

A 2026 review maps how post-translational modifications tune ferroptosis defenses in hepatocellular carcinoma and drive resistance to therapy.

A 2024 review examines how artificial intelligence is accelerating human living organoid research, from disease modeling to drug…

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds