Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

CD3xCD20 bispecific antibodies show salvage activity after CAR-T failure in LBCL

Meta-analysis of 1,169 patients found CD3xCD20 bispecific antibodies produced meaningful responses after CAR-T failure in relapsed/refractory large B-cell lymphoma.

By Dr. Revathy Mohan V.R., MBBS · 2 days ago · 6 min read

Oncology·JCO

Genomic innovations are reshaping cancer prevention and precision oncology

A 2026 review describes how sequencing, liquid biopsy, transcriptomics and CRISPR are changing cancer detection, risk assessment and…

2 days ago

Oncology·Front Immunol

Autophagy in Cancer Progression Links Metabolism, Stemness, and Immunity

A Frontiers in Immunology review maps how autophagy shapes cancer metabolism, stemness, immune evasion, and resistance across key…

2 days ago

Oncology·Front Immunol

HGF-MET axis restrains cytotoxic CD8 T-cell immunity in melanoma

In melanoma models, MET marks highly cytotoxic CD8 T cells, while prior HGF exposure dampens their killing and…

2 days ago

Oncology·Front Immunol

Laryngeal Dysplasia and Immune Remodeling: When Prevention Becomes Testable

A Frontiers perspective proposes a framework to separate prognostic immune signals from true preventive targets in laryngeal dysplasia.

2 days ago

Oncology·Nat Rev Onc

Microbiota-derived cholesterol metabolite suppresses colorectal cancer growth

A microbiota-derived cholesterol metabolite, 4-C-3, suppressed colorectal cancer growth in preclinical models and countered KRAS-linked resistance.

2 days ago

Oncology·Nat Rev Onc

Prostate cancer risk linked to lower immune surveillance in blood and genetics

Prospective and genetic analyses link lower immune surveillance to prostate cancer risk, with IL15, FLT3LG and genetic signals…

2 days ago

Oncology·Fierce HC

Color Health links with NCI cancer centers to speed oncology intake

Color Health is partnering with 10 NCI-designated cancer centers to streamline oncology intake, records prep, and faster treatment…

2 days ago

Oncology·ClinicalTrials

CM93 phase 1 trial targets EGFR-altered recurrent glioblastoma

NYU Langone is launching a phase 1 surgical window study of CM93 in recurrent glioblastoma with EGFR alteration…

2 days ago

Oncology·medRxiv

Cell-free DNA fragmentation classifier detects early-stage cancer in preprint study

A preprint describes Blackjack, a cfDNA fragmentation classifier that detected early cancers with high AUC in external validation…

2 days ago

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.