Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

CD40/CD28 co-stimulation boosts CAR-T activity in solid tumors

A preclinical CAR-T strategy combining CD40 and CD28 co-stimulation reprogrammed solid-tumor immunity, improved persistence, and enhanced anti-PD-1 synergy.

By Dr. Revathy Mohan V.R., MBBS · 2 days ago · 6 min read

Oncology·bioRxiv

Ultra-low-dose EGFR combinations delay resistance in cancer models

Ultra-low-dose combinations of multiple EGFR inhibitors restrained resistance in cancer models better than single agents at similar growth…

2 days ago

Oncology·ESMO Open

KEYNOTE-671 5-Year Analysis Examines Non-pCR Early-Stage NSCLC Outcomes

Exploratory KEYNOTE-671 analysis examines early-stage NSCLC patients without pCR after perioperative pembrolizumab, extending follow-up to 5 years.

2 days ago

Oncology·ESMO Open

RNA-Based Therapy in HCC Targets Tumor Plasticity at ESMO Open

ESMO Open abstract examines an RNA-based therapy for hepatocellular carcinoma, with attention to pharmacodynamics and safety in tumor…

2 days ago

Oncology·ScienceDaily

Cancer antioxidants block T cells and weaken immunotherapy, study finds

Tumors use PRDX1 antioxidants to suppress T cells in mice and human cancer samples, revealing a new route…

2 days ago

Oncology·Nature

Nutritional Indices Linked to Colorectal Cancer History in NHANES Study

NHANES data linked poorer nutritional indices with self-reported colorectal cancer history in middle-aged and older adults, with sex…

2 days ago

Oncology·BBC Dental

Neuroendocrine Cancer Awareness Lags as Diagnosis Takes Years

Rachel Wood’s story exposes delayed recognition of neuroendocrine cancer and the need for better clinician training and specialist…

2 days ago

Oncology·BBC Dental

Breast Cancer Mammograms Catch Hidden Tumors Despite No Symptoms

Two women describe breast cancers found on routine mammograms despite feeling well, reinforcing the value of regular screening.

2 days ago

Oncology·BBC Dental

Young people and cancer: family campaign after Ewing sarcoma death

After her son’s death from Ewing sarcoma, a mother is urging earlier cancer consideration in young people with…

2 days ago

Oncology·Nat Rev Neuro

Breast cancer radiomics model predicts lymphovascular invasion before surgery

A multicenter breast MRI radiomics study found preoperative models could predict lymphovascular invasion, but external calibration weakened.

2 days ago

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.