Immunology

Clinical evidence, research, and medical intelligence in Immunology.

Immune Tolerance in Tissue Repair Gains Focus in Frontiers Research Topic

Frontiers in Immunology opens a Research Topic on immune tolerance in tissue repair, spanning regulatory cells, fibrosis, regeneration, and graft acceptance.

By Dr. A. Nikhil Krishnan, MBBS · Oct 20, 2026 · 5 min read

Immunology·Front Immunol

B cells and autoimmunity drive new Frontiers immunology research topic

Frontiers in Immunology launches a research topic on B cells, memory subsets, ectopic lymphoid structures, and targeted autoimmune…

Oct 20, 2026

Immunology·PLOS Med

SGK1 Emerges as a Myeloid Senescence Candidate in ME/CFS

Transcriptomic and cell-based analyses identify SGK1 as a candidate regulator of myeloid senescence in ME/CFS, with autophagy-lysosome links.

Oct 20, 2026

Immunology·JCI

Preterm immune system shows divergent inflammatory imprinting in early life

Longitudinal profiling of 38 preterm infants found severe BPD and infection left distinct, lasting immune signatures in early…

Oct 20, 2026

Immunology·ACC-PRO

Immune Boost Capital backs Orthrus Therapeutics in autoimmune tolerance push

Immune Boost Capital is investing in Orthrus Therapeutics as the company advances antigen-specific immune tolerance for autoimmune disease.

Oct 20, 2026

Immunology·JCI

COVID-19 Vaccines Trigger Dose-Dependent IFN Programs in Myeloid Cells

Single-cell profiling in 31 adults mapped distinct interferon programs after mRNA and adenovirus COVID-19 vaccines, separating priming from…

Oct 20, 2026

Immunology·Nat Immunol

Dendritic Cells Sense Microbial Adhesion via Piezo1 in Skin Infection

Mouse skin infection data show microbial adhesion activates Piezo1 on CD11c+ myeloid cells, triggering early neutrophil recruitment before…

Oct 19, 2026

Immunology·Nat Immunol

Distal IRF4 element drives human Treg instability under inflammation

Human regulatory T cells lose suppressive identity under inflammatory cytokines, but deleting a distal IRF4 element preserves lineage…

Oct 19, 2026

Immunology·Nat Immunol

Epithelial antigen presentation drives barrier memory in the intestine

Intestinal epithelial cells can present cytosolic bacterial antigens through MHC II, shaping antigen-specific CD4 tissue-resident memory and barrier…

Oct 19, 2026

Immunology·Front Immunol

HMGB1 peptide study separates anti-NETotic and anti-biofilm activity

A Frontiers in Immunology study maps HMGB1 B-box peptides, separating anti-NETotic PKC inhibition from anti-biofilm DNA binding in…

Oct 19, 2026

Immunology

Clinical evidence, research, and medical intelligence in Immunology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.