Immunology

Clinical evidence, research, and medical intelligence in Immunology.

Maternal autoantibodies linked to preterm birth in pregnancy cohorts

Proteome-wide profiling across eight cohorts found maternal autoantibody patterns tied to pregnancy and a distinct signature associated with preterm birth.

By Dr. A. Nikhil Krishnan, MBBS · Oct 19, 2026 · 5 min read

Immunology·bioRxiv

Granzyme B replenishment sustains CD8 T-cell cytotoxicity

A bioRxiv preprint finds effector CD8+ T cells selectively restore granzyme B after degranulation, sustaining serial killing despite…

Oct 19, 2026

Immunology·Front Immunol

Multi-pathogen Vaccines Face Interference Challenges in Biodefense Design

A Frontiers in Immunology review examines how multi-pathogen biodefense vaccines can succeed or fail, and why interference mechanisms…

Oct 19, 2026

Immunology·PNAS

IgAse Uses CH1 Gate to Cleave IgA1 and IgA2

PNAS structural work shows how the commensal metallopeptidase IgAse uses a CH1-mediated gate to cleave both IgA subclasses.

Oct 19, 2026

Immunology·ScienceDaily

Supercentenarians Show High Levels of Killer CD4 T Cells

Supercentenarians carried unusually high levels of CD4 cytotoxic T cells, with clonal expansion suggesting immune adaptation in extreme…

Oct 18, 2026

Immunology·ScienceDaily

AI predicts vaccine response from pre-vaccine antibody patterns

Researchers used AI and antibody fingerprints in over 4,000 people to predict who would mount strong or weak…

Oct 18, 2026

Immunology·JCI

FcRn antagonists alter albumin handling in distinct ways

Cellular analyses explain why some FcRn antagonists lower albumin, identifying FcRn degradation and ligand competition as key mechanisms.

Oct 18, 2026

Immunology·Nature

Aged T Cells Regain Young-Like Surveillance After Viscosity Priming

Elevated fluid viscosity briefly restored young-like surveillance behaviors in aged human T cells, especially CD4+ memory cells, in…

Oct 18, 2026

Immunology·JCI

CCR2 Knockout Mice Show Monocyte Migration Defects and Weakened Th1 Responses

CCR2 knockout mice showed impaired monocyte migration and reduced Th1 cytokine responses, linking chemokine signaling to coordinated innate…

Oct 18, 2026

Immunology·ScienceDaily

Chronic Fatigue Study Links Long Covid, ME/CFS, PTSD and Autoimmune Disease

A 3D genomics study links long Covid, ME/CFS, PTSD, rheumatoid arthritis and MS to shared immune and metabolic…

Oct 18, 2026

Immunology

Clinical evidence, research, and medical intelligence in Immunology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.