Immunology

Clinical evidence, research, and medical intelligence in Immunology.

Immunology group divided over California’s $8.4 billion research ballot measure

Internal emails show the American Association of Immunologists split over California’s $8.4 billion ballot measure to fund immunology research.

By Dr. A. Nikhil Krishnan, MBBS · Oct 19, 2026 · 4 min read

Immunology·Brain

Hyaluronidase-Facilitated SCIG PK Compared in Pediatric and Adult PI Patients

Three phase 3 trials examined hyaluronidase-facilitated subcutaneous immunoglobulin 10% pharmacokinetics in pediatric and adult primary immunodeficiency patients.

Oct 19, 2026

Immunology·Nat Immunol

AMBRA1 drives NLRP3 inflammasome activation in inflammatory disease

AMBRA1 binds NLRP3, promotes inflammasome activation, and lowers inflammatory responses in mouse models of sepsis, colitis, and endotoxic…

Oct 19, 2026

Immunology·Nat Immunol

ANKRD11 emerges as a target for CD8 T cell dysfunction in HBV and cancer

Humanized mouse data identify ANKRD11 as an epigenetic brake on CD8 T cells, with effects on HBV control,…

Oct 19, 2026

Immunology·Nat Immunol

AID targets LINE-1 elements to drive antibody somatic hypermutation

New work links upstream LINE-1 elements and HUSH recruitment to AID targeting, clarifying how somatic hypermutation is directed…

Oct 19, 2026

Immunology·Front Immunol

Fetal bovine serum and calf serum differ sharply in lipid mediator content

Fetal bovine and calf serum diverge in endocannabinoids, fatty acids, oxylipins, and cytokines, with direct implications for cell…

Oct 19, 2026

Immunology·Nat Immunol

Autoantibody Source Linked to BAM Cells After COVID-19

Single-cell profiling tied post-COVID autoantibodies to atypical memory B cells with TLR7-linked activation and stronger type III interferon…

Oct 19, 2026

Immunology·Nat Immunol

Zbtb44 loss drives colitis through unchecked IFN-γ in T cells

Mouse data identify Zbtb44 as a brake on intestinal inflammation, with SUMOylation-dependent control of T-bet and IFN-γ in…

Oct 19, 2026

Immunology·Nat Immunol

Intestinal epithelial cell antigen presentation shapes CD4 T cell memory

Cytosolic bacterial antigens drove stronger mucosal CD4 T cell responses and tissue-resident memory than membrane-bound antigens in a…

Oct 19, 2026

Immunology·Front Immunol

Pulmonary Sepsis Review Maps Pathogen-Linked Immune Endotypes

Frontiers review links pulmonary pathogens to sepsis phenotypes and transcriptomic endotypes, with implications for biomarker-guided precision therapy.

Oct 19, 2026

Immunology

Clinical evidence, research, and medical intelligence in Immunology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.