Critical Care

Trials, guidelines and clinical evidence across Critical Care.

CRT-Guided Resuscitation Lowers Early Fluid Input in Septic Shock

In septic shock, capillary refill time-guided resuscitation reduced 6-hour fluid input versus lactate-guided care, with exploratory outcome signals.

By Dr. Aishwarya N., MBBS · Oct 26, 2026 · 5 min read

Critical Care·Nature

Braden score outperforms vasoactive dose for ICU pressure injury risk

In ICU patients receiving early vasoactive support, the first-day Braden score predicted pressure injury better than vasopressor dose…

Oct 26, 2026

Critical Care·medRxiv

Trauma Organ Dysfunction Trajectories Map Distinct Immune Profiles

Five organ dysfunction trajectories after severe trauma mapped to distinct immune signatures, including neutrophil, endothelial, and repair pathways.

Oct 26, 2026

Critical Care·EHJ

Empirical Antifungal Treatment in Influenza-Associated ARDS Examined in Bayesian Framework

A Bayesian perspective examines empirical antifungal treatment in critically ill patients with influenza-associated ARDS, where fungal coinfection remains…

Oct 25, 2026

Critical Care·medRxiv

ICU Bacterial Profile and Antibiotic Resistance in Mbeya Study

In Mbeya ICU patients with suspected sepsis, culture positivity reached 41.7% and multidrug resistance was near universal among…

Oct 25, 2026

Critical Care·NNU

UCI Health Irvine Nurses Rally Over ICU Staffing and Night Shift Cuts

UCI Health Irvine nurses plan a rally over ICU understaffing and removal of night-shift CNAs, citing patient safety…

Oct 25, 2026

Critical Care·BMJ Open

ARDS management in trauma care gains focus on phenotyping and ECMO

A review of acute respiratory distress syndrome in trauma care emphasizes lung-protective ventilation, fluid balance, and emerging precision…

Oct 25, 2026

Critical Care·BMJ Open

ICU urinary leakage prevention gaps found in catheter care baseline review

A baseline review in a Chinese ICU found wide gaps between evidence and practice for urinary leakage prevention…

Oct 24, 2026

Critical Care·Brain

Sepsis Histone H3 Linked to Mortality and Coagulopathy in ICU Patients

Extracellular histone H3 was linked to low antithrombin, low platelets, and mortality in sepsis, pointing to injury at…

Oct 24, 2026

Critical Care·NLM Alerts

Septic Shock Research Output Examines Income and Gender Gaps

A meta-epidemiological study in septic shock examines how scientific output varies by country income and gender across critical…

Oct 24, 2026

Critical Care

Trials, guidelines and clinical evidence across Critical Care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.