Critical Care

Trials, guidelines and clinical evidence across Critical Care.

Exercise self-efficacy links social support to ICU recovery in new study

In 300 ICU transfer patients, social support was linked to better physical function, with exercise self-efficacy explaining part of the relationship.

By Dr. Aishwarya N., MBBS · Oct 20, 2026 · 5 min read

Critical Care·Front Immunol

Sepsis immunoparalysis trajectories reshape monitoring and treatment

A Frontiers review maps sepsis-induced immunoparalysis, tracking immune trajectories, biomarkers, and the limits of phenotype-guided therapy.

Oct 19, 2026

Critical Care·BMJ Open

Photobiomodulation Trial Targets Diaphragm Weakness in Ventilated ICU Patients

BMJ Open protocol for a multicentre triple-blind trial tests photobiomodulation with a static magnetic field to protect the…

Oct 19, 2026

Critical Care·JAMA IM

ICU Nutrition in 2026: Phase-Based Feeding, Protein Targets, and Immunonutrition

Phase-based ICU nutrition favors trophic enteral feeding early, restrained energy and protein in week one, then higher targets…

Oct 19, 2026

Critical Care·JAMA IM

Isoflurane Sedation Fails to Reduce Mortality in Acute Hypoxemic Respiratory Failure

SAVE-ICU found no mortality benefit for isoflurane-based inhaled sedation versus intravenous sedation in ventilated adults with acute hypoxemic…

Oct 19, 2026

Critical Care·JAMA IM

Dobutamine Plus Norepinephrine Cuts Postoperative AKI in Septic Shock

In septic shock patients undergoing surgical source control, intraoperative dobutamine plus norepinephrine lowered 7-day postoperative AKI versus norepinephrine…

Oct 19, 2026

Critical Care·Cochrane

Daily sedation interruption review updates ICU ventilation evidence

Cochrane’s updated review re-examines daily sedation interruption in mechanically ventilated adults and children as ICU sedation practice evolves.

Oct 19, 2026

Critical Care·JCI

Sepsis endothelial dysfunction framework links biomarkers to bedside care

JCI review frames sepsis-associated endothelial dysfunction as dynamic endotheliopathy, linking phenotypes, biomarkers, and organ-specific injury.

Oct 17, 2026

Critical Care

Trials, guidelines and clinical evidence across Critical Care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.