Critical Care

Trials, guidelines and clinical evidence across Critical Care.

Prone Positioning Pressure Injury Prevention in Ventilated ICU Patients

A systematic review found bundled prevention strategies may reduce pressure injuries in mechanically ventilated patients placed in prone positioning.

In PREV-HAP, IFN-γ restored monocyte markers but did not prevent ventilator-associated pneumonia, pointing to lymphoid immune deficits.

In ICU patients with sepsis and type 2 diabetes, vancomycin started at 48 hours or later was tied…

In ICU patients with community-acquired pneumonia, higher glycemic variability was tied to more delirium and higher 1-year mortality…

A sham-controlled pig study found endotracheal UVA therapy lowered early airway Pseudomonas burden and lobar pneumonia, without major…

Japan’s EURASSIA adaptive platform trial will test sepsis treatments across ICU centers, with 90-day survival as the primary…

DailyMed’s updated norepinephrine label outlines IV dosing, monitoring, ischemia risks, and key drug interactions for acute hypotension.

A Chinese randomized trial will test Shenfu Injection against placebo to improve diaphragm function and speed ventilator weaning…

BMJ Open protocol will map decision aids for life-sustaining treatment and end-of-life care in emergency and intensive care…

A prospective registry study will test twice-weekly echocardiography and cardiac biomarkers for right ventricular injury during VV-ECMO in…

Critical Care

Trials, guidelines and clinical evidence across Critical Care.

In Brief The 5-minute rounds