Rheumatology

Trials, guidelines and clinical evidence across Rheumatology.

Treat-to-target recommendations set new goals in GCA and PMR

New treat-to-target recommendations for giant cell arteritis and polymyalgia rheumatica define remission, ischemia prevention, and shared decision-making.

By Dr. A. Nikhil Krishnan, MBBS · 5 days ago · 6 min read

Rheumatology·ARD

EULAR/ACR Criteria Standardize Adult and Juvenile Idiopathic Myositis

EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies aim to standardize research definitions across age groups.

5 days ago

Rheumatology·ARD

DMARD Use Shapes Anti-TNF Persistence in Rheumatoid Arthritis

In a large British registry, methotrexate-based combinations improved anti-TNF persistence in rheumatoid arthritis, while leflunomide and sulfasalazine alone…

5 days ago

Rheumatology·ARD

NLRP1 Mutations Linked to New Autoinflammatory- Autoimmune Syndrome

Researchers describe NAIAD, a newly named syndrome linked to NLRP1 mutations, combining autoinflammatory and autoimmune features.

5 days ago

Rheumatology·Nat Rev Onc

Difficult-to-treat rheumatoid arthritis and PsA linked to damage and comorbidity

Ultrasound-confirmed inflammation identified a severe difficult-to-treat phenotype in rheumatoid arthritis and peripheral psoriatic arthritis, tied to damage and…

5 days ago

Rheumatology·ARD

PI3Kδ Pathway Emerges as Therapeutic Target in Sjögren’s Syndrome

PI3Kδ signaling is active in Sjögren’s glands, and seletalisib reduced lymphocytic infiltration, chemokines, and autoantibodies in a mouse…

5 days ago

Rheumatology·ARD

mtDNA Variant m.16519C Linked to Rapid Knee Osteoarthritis Progression

A meta-analysis and cybrid study link mtDNA variant m.16519C to faster knee osteoarthritis progression through mitochondrial and inflammatory…

5 days ago

Rheumatology·ARD

Rheumatoid arthritis onset tracks latitude, but wealth explains the gradient

Global METEOR registry analysis links higher latitude to older rheumatoid arthritis onset, with country socioeconomic status largely explaining…

5 days ago

Rheumatology·ARD

Lupus nephritis pulse steroids: selective use may better balance benefit and harm

A review of lupus nephritis induction therapy weighs pulse steroids against oral glucocorticoids, favoring selective use over universal…

5 days ago

Rheumatology·Br J Cancer

Type 2 Diabetes in Sjögren’s Disease Linked to Distinct Serology

In Sjögren’s disease, type 2 diabetes tracked with higher metabolic burden and lower anti-SSB/La and C3 positivity in…

5 days ago

Rheumatology

Trials, guidelines and clinical evidence across Rheumatology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.