Rheumatology

Trials, guidelines and clinical evidence across Rheumatology.

TAS5315 rheumatoid arthritis trial shows numerical efficacy with bleeding risk

TAS5315 missed its primary endpoint in methotrexate-refractory rheumatoid arthritis, but showed numerical efficacy gains and bleeding concerns over 36 weeks.

By Dr. A. Nikhil Krishnan, MBBS · 5 days ago · 5 min read

Rheumatology·ARD

EULAR updates hip and knee osteoarthritis non-pharmacologic care

EULAR issues a 2023 update on non-pharmacological core care for hip and knee osteoarthritis, centering education, exercise, weight…

5 days ago

Rheumatology·PLOS Med

Silicon-based agent eases arthritis in RA mouse model but not vestibular loss

In a collagen-induced rheumatoid arthritis mouse model, an oral silicon-based agent improved joint inflammation but did not measurably…

6 days ago

Rheumatology·ARD

Rheumatology guidelines gain visibility in altmetric and citation analysis

A cross-sectional analysis of 127 rheumatology guidelines found rising publication volume and mapped online attention against citation performance.

6 days ago

Rheumatology·medRxiv

ctDNA May Flag Occult Cancer in Early-Onset Systemic Sclerosis and Dermatomyositis

Plasma ctDNA identified most cancers before diagnosis in early-onset systemic sclerosis and dermatomyositis, suggesting a new risk-stratification tool.

6 days ago

Rheumatology·ARD

EULAR sets minimal reporting standards for synovial tissue research

EULAR proposes minimal reporting requirements for synovial tissue research to improve transparency across biopsy methods, processing, and molecular…

6 days ago

Rheumatology·JNCI

Vaccination Uptake and Respiratory Infection Burden in Lupus Cohort Study

Population-based cohort study in systemic lupus erythematosus examines vaccination uptake trends and respiratory infection burden over time.

6 days ago

Rheumatology·ARD

Chlamydia-Associated Reactive Arthritis and the Case for Combination Therapy

Recent trial data suggest combination antibiotics may treat Chlamydia-induced reactive arthritis, reshaping diagnosis and management of this spondyloarthritis.

7 days ago

Rheumatology·ARD

Sjögren’s Tool for Assessing Response advances primary Sjögren’s trial endpoints

Researchers developed STAR, a composite responder index for primary Sjögren's syndrome, with strong face validity and planned prospective…

7 days ago

Rheumatology·ARD

Glucocorticoid Use in Rheumatoid Arthritis Declines After Diagnosis in Danish Cohort

Danish cohort data show glucocorticoid use is concentrated early in rheumatoid arthritis care, with one-year infection estimates remaining…

7 days ago

Rheumatology

Trials, guidelines and clinical evidence across Rheumatology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.