Rheumatology

Trials, guidelines and clinical evidence across Rheumatology.

Anti-MDA5 RP-ILD: trajectory framework for recognizing treatment non-response

A Frontiers in Immunology review proposes a trajectory-based framework for spotting treatment non-response in anti-MDA5 RP-ILD before rescue options close.

By Dr. A. Nikhil Krishnan, MBBS · 2 days ago · 5 min read

Rheumatology·Front Immunol

Serum Itaconate Falls in Untreated PMR and Rises With Therapy

Prospective data in polymyalgia rheumatica link serum itaconate to treatment state, inflammation, and glucocorticoid exposure in serial samples.

2 days ago

Rheumatology·ARD

Lupus Study Links Reduced X Chromosome Inactivation Skewing to Interferon Signalling

Females with systemic lupus erythematosus showed less X chromosome inactivation skewing, tied to interferon signalling rather than genetics…

2 days ago

Rheumatology·ARD

Novel autoantibodies may aid Sjögren disease diagnosis when anti-SSA is negative

A study in Annals of the Rheumatic Diseases examines novel autoantibodies that may improve diagnosis of anti-SSA negative…

2 days ago

Rheumatology·Nature

Ianalumab modestly lowers Sjögren disease activity in phase III trials

Two phase III trials found ianalumab 300 mg monthly modestly reduced Sjögren disease activity, but key secondary end…

2 days ago

Rheumatology·ARD

Global SLE incidence and prevalence vary sharply by sex and region

A systematic modeling study estimates global systemic lupus erythematosus burden, with large sex, age, and regional differences and…

3 days ago

Rheumatology·ARD

Obinutuzumab Trial Tests B-Cell Depletion in Lupus Nephritis

A randomized, double-blind placebo-controlled study evaluates obinutuzumab for proliferative lupus nephritis, a high-risk renal manifestation of SLE.

3 days ago

Rheumatology·ARD

Gut virome study links phage loss to rheumatoid arthritis and lupus

Shotgun sequencing of 476 Japanese linked reduced crAss-like phages to rheumatoid arthritis and lupus, with virus-bacterium ties in…

3 days ago

Rheumatology·ARD

EULAR APS recommendations set anticoagulation standards for adults

EULAR guidance defines antithrombotic and pregnancy management in adult antiphospholipid syndrome, with warfarin favored and rivaroxaban avoided in…

3 days ago

Rheumatology·ARD

Axial Spondyloarthritis Review Tracks Advances in Diagnosis, Imaging, and Therapy

A 2024-2025 review of axial spondyloarthritis details new immune insights, MRI consensus, ultrasound use, AI tools, and treatment…

3 days ago

Rheumatology

Trials, guidelines and clinical evidence across Rheumatology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.