Rheumatology

TNF reverse signaling drives bone formation in axial spondyloarthritis

Macrophage tmTNF reverse signaling activates NF-κB and bone-forming pathways in radiographic axial spondyloarthritis, pointing to a targeted strategy.

PARE Organizations Expand Rheumatology Support Beyond Abstract Advocacy

PARE organizations in rheumatology move from abstract aims to practical patient support, advocacy, education, and community engagement.

Still’s disease: IL-1 and IL-6 inhibitors lead efficacy in EULAR review

A systematic review for EULAR/PReS found IL-1 and IL-6 inhibitors most effective in Still’s disease, with MAS responding…

Rheumatology·Nature

PVT1 and STAT3 rise with Behçet’s disease activity in blood cells

Peripheral blood transcript data link PVT1 and STAT3 to Behçet’s disease activity, with strong ROC performance and a…

Septic Arthritis: 2 Weeks of Antibiotics Matched 4 Weeks After Surgery

Two weeks of targeted antibiotics after surgical drainage was noninferior to four weeks for native joint septic arthritis,…

IgG4-RD relapse rises after stopping maintenance therapy in WInS trial

In stable IgG4-related disease, stopping glucocorticoids and immunosuppressants led to far more relapses than continuing maintenance therapy.

RA Prevention: How At-Risk Patients View Risk Disclosure and Early Treatment

Qualitative review shows at-risk rheumatoid arthritis patients see benefits in risk disclosure, but uncertainty and treatment burden can…

Psoriatic Arthritis Mortality in Sweden Linked to Comorbidity Burden

Swedish nationwide data found slightly higher all-cause mortality in psoriatic arthritis, largely explained by comorbidity and concentrated in…

JAK-STAT Inhibition Normalizes Salivary Gland Inflammation in Sjögren’s Disease

Human tissue studies found JAK-STAT activation and interferon-driven immune signaling in Sjögren’s disease, corrected ex vivo by JAK…