Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Hypofractionated Whole-Brain Radiotherapy Trial Targets Melanoma Brain Metastases

A phase II randomized trial is testing hypofractionated whole-brain radiotherapy against standard dosing in melanoma brain metastases, with toxicity and survival endpoints.

By Dr. Revathy Mohan V.R., MBBS · 20 hrs ago · 6 min read

Oncology·ClinicalTrials

KRAS G12D Trial Tests BI 4015092 Alone and With Cetuximab

Boehringer Ingelheim’s first-in-human phase 1 trial will test BI 4015092 alone and with cetuximab in advanced KRAS G12D…

20 hrs ago

Oncology·ClinicalTrials

Pembrolizumab Added to Adjuvant Chemo in Resected NSCLC in Phase 3 Trial

Phase 3 ALCHEMIST trial tests pembrolizumab after or during chemotherapy for resected stage II-IIIB non-small cell lung cancer.

20 hrs ago

Oncology·ClinicalTrials

Tisotumab Vedotin Trial Targets Recurrent Vulvar Squamous Cell Carcinoma

A phase 2 study will test tisotumab vedotin in recurrent or metastatic vulvar squamous cell carcinoma with objective…

20 hrs ago

Oncology·ClinicalTrials

Head and neck cancer trial tests radiation without PTV margin

City of Hope is testing whether removing the planning tumor volume from head and neck radiation can reduce…

21 hrs ago

Oncology·ClinicalTrials

Selumetinib trial targets recurrent pediatric low-grade glioma

Phase I/II trial of selumetinib in recurrent pediatric low-grade glioma tests dosing, safety, and re-treatment in 217 patients.

21 hrs ago

Oncology·Cancer Cell

Architectural Protein Abundance Linked to Satellite DNA Expansion in Cancer Cell Study

A Cell Press study links architectural protein abundance with pericentromeric satellite expansion, pointing to a reciprocal constraint in…

24 hrs ago

Oncology·PNAS

Glucocorticoid receptor shapes germinal center B cells and DLBCL therapy

Mouse and human data show glucocorticoid receptor activity guides germinal center B-cell homeostasis, plasmacytic differentiation, and glucocorticoid sensitivity…

1 day ago

Oncology·MedCity

FDA Approves Pimjetmi for Tenosynovial Giant Cell Tumor

FDA approval of Pimjetmi gives adults with tenosynovial giant cell tumor a new once-daily option backed by Phase…

1 day ago

Oncology·ScienceDaily

Fructose may drive ovarian cancer spread after chemotherapy

Preclinical ovarian cancer research links fructose and statins to cell detachment, metastasis, and cholesterol suppression after chemotherapy.

1 day ago

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.