Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Metformin Alters ESR1 Splicing in Breast Cancer Cells, Density Dependent

Metformin changed ESR1 splicing in breast cancer cells only under specific culture conditions and lowered HMGA1a and RBM3 protein in a preprint study.

By Dr. Revathy Mohan V.R., MBBS · Nov 6, 2026 · 5 min read

Oncology·Cancer Disc

RNA Vaccination Boosts T Cells in Glioblastoma Adoptive Cell Therapy

A Cancer Discovery study examines how RNA vaccination expands and brain-licenses T cells to improve adoptive cell therapy…

Nov 6, 2026

Oncology·Cancer Disc

BRAF Inhibition Triggers CAF Nuclear Remodeling Through ROCK Signaling

BRAF inhibition and matrix stiffness converge on ROCK-driven nuclear remodeling in cancer-associated fibroblasts, promoting beta-catenin accumulation and CAF…

Nov 6, 2026

Oncology·Front Immunol

Systemic Inflammation and Thoracic Radiation Predict CIP in Esophageal Cancer

Baseline systemic inflammation and thoracic radiation shaped checkpoint inhibitor pneumonitis risk in esophageal squamous cell carcinoma, with stronger…

Nov 6, 2026

Oncology·Front Immunol

PD-1/PD-L1 Inhibitor IrAE Network Analysis Maps Core Symptom Clusters

Network analysis of FAERS and JADER reports mapped core suspected irAE patterns with PD-1/PD-L1 inhibitors, separating gastrointestinal and…

Nov 6, 2026

Oncology·Front Immunol

Dendritic Cell Fate Plasticity Reframes Tumor Immunity in Cancer

A 2026 Frontiers in Immunology review recasts dendritic cell dysfunction as active fate hijacking and maps reprogramming targets…

Nov 6, 2026

Oncology·ClinicalTrials

TRB191 Phase 1 Trial Begins in Extensive-Stage Small Cell Lung Cancer

Novartis is launching a phase 1 trial of TRB191 in extensive-stage small cell lung cancer, with safety, PK,…

Nov 5, 2026

Oncology·ClinicalTrials

FES PET/MRI Trial Aims to Improve Staging in Lobular Breast Cancer

A University of Wisconsin trial will test whether 18F-FES PET/MRI detects occult invasive lobular breast cancer missed on…

Nov 5, 2026

Oncology·ClinicalTrials

Head and Neck Cancer Study Tracks DNA, ctDNA, and Microbiome

A Danish cohort study will profile tumor DNA, RNA, ctDNA, and microbiome signals to refine diagnosis and recurrence…

Nov 5, 2026

Oncology·ClinicalTrials

COMFORT trial to test AI reading for kidney and prostate tumors

COMFORT will test whether AI-assisted reading improves kidney and prostate tumor assessment, clinician usability, fairness, and privacy risk.

Nov 5, 2026

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.