Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Phase 3 Trial Tests Mocertatug Rezetecan in MMRp Endometrial Cancer

GSK’s BEHOLD-Endometrial02 phase 3 trial will test mocertatug rezetecan plus checkpoint blockade as maintenance therapy in MMRp endometrial cancer.

A preprint shows a palmitoylation-sensitive peptide assembly alters KRAS localization, ERK/AKT signaling, and viability in pancreatic cancer cells.

A new hierarchical machine-learning framework classifies tumors from broad cancer groups to molecular subtypes with interpretable gene ranking.

Revolution Medicines says Rasonque generated $198 million in five weeks after U.S. approval, with more than 5,000 patients…

A Cell Press abstract describes a conditionally replicative adenovirus tagged with red fluorescent protein to aid tracking in…

Single-cell multiplexed immunofluorescence identified protein coexpression states in breast cancer and linked some clusters to FDG uptake.

A JCI study examines how obesity-linked hormonal and metabolomic changes may reshape the tumor microenvironment and alter immunotherapy…

Nature issued a correction to the zanubrutinib plus R-CHOP phase II DLBCL study after the updated version of…

A two-center study found CT radiomics may help predict thoracic vertebral compression fractures after radiotherapy in esophageal squamous…

A systematic review of 15 studies finds HPV, especially genotype 16, may contribute to some oral squamous cell…

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds