Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Daraxonrasib Resistance in Pancreatic Cancer May Yield to Allele-Specific Salvage Therapy

AACR work describes allele-specific resistance mechanisms to daraxonrasib in pancreatic cancer and explores salvage strategies to bypass treatment escape.

By Dr. Revathy Mohan V.R., MBBS · 7 days ago · 5 min read

Oncology·Cancer Disc

Regulatory T-cell influx linked to acquired PD-1 resistance in cancer models

Mathematical and mouse models identify regulatory T-cell influx as a driver of acquired resistance to PD-1 immunotherapy in…

7 days ago

Oncology·Sci Transl Med

CAR-NK Cells for Solid Tumors Face Barriers Despite Safety Advantages

CAR-NK cell therapy offers safer off-the-shelf immunotherapy, but solid tumors still block infiltration, persistence, and durable antitumor activity.

7 days ago

Oncology·JAMA Open

Kansas Lung Cancer Mortality Maps Reveal County-Level Hotspots and Risk Patterns

Spatial modeling across 105 Kansas counties linked lung cancer mortality to older age, rurality, and clustered geography, with…

7 days ago

Oncology·Front Immunol

Rectal Cancer iTNT Microbiome Study Draws Caution on Biomarker Validation

A Frontiers commentary examines microbiome-metabolome findings in rectal cancer iTNT, stressing response definitions, sampling bias, and validation needs.

7 days ago

Oncology·Front Immunol

USP15 drives colorectal cancer immune evasion through PTBP1 and CXCR4

USP15 promotes M2 macrophage polarization and immune evasion in colorectal cancer by stabilizing PTBP1 and raising CXCR4 expression.

7 days ago

Oncology·Front Immunol

EGFR-mutant lung cancer shows MET, ALK, KRAS, and BRAF clonal shifts

A lung adenocarcinoma case traces EGFR resistance across three biopsies, with MET and ALK loss, KRAS/BRAF bypass emergence,…

7 days ago

Oncology·BMJ Open

Blood Test Trends Show Early Promise in Cancer Detection Review

A scoping review of 90 studies found repeated blood test trends may aid cancer detection, with strongest evidence…

7 days ago

Oncology·BMJ Open

IMAGINE trial tests mainstreaming model for hereditary cancer genetic testing

BMJ Open protocol for IMAGINE, a randomized trial of culturally and linguistically adapted hereditary cancer multigene panel testing…

7 days ago

Oncology·HHS

PFAS Exposure Linked to Higher ER-Negative Breast Cancer Risk in NIH Study

NIH analysis links higher blood levels of PFOA and PFOS to increased ER-negative breast cancer risk, with no…

7 days ago

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.