Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Digital pathology infrastructure and FDA pathways shape AI drug development

A BMJ Open review maps the infrastructure, governance and regulatory pathways needed to move digital and AI pathology from biobanks to companion diagnostics.

By Dr. Revathy Mohan V.R., MBBS · 5 days ago · 5 min read

Oncology·Nat Rev Onc

Pediatric cancer predisposition shifts toward earlier detection and prevention

A Nature Reviews perspective outlines new surveillance, prevention and AI strategies for pediatric cancer predisposition syndromes and earlier…

5 days ago

Oncology·NIH

Young-Onset Cancer Incidence Trends Point to Onset and Diagnosis Shifts

A disease-modeling study separates birth-cohort onset effects from diagnostic timing changes in rising young-onset cancer incidence.

5 days ago

Oncology·NIH

Sitagliptin shows phase 2 activity against gemcitabine-resistant pancreatic cancer

A phase 2 trial found sitagliptin plus gemcitabine and nab-paclitaxel produced responses in advanced pancreatic cancer with no…

5 days ago

Oncology·ClinicalTrials

RAPID trial tests two-stage surgery for unresectable colorectal liver metastases

A prospective trial will test RAPID surgery for unresectable colorectal liver metastases, tracking graft growth, resection completion, and…

5 days ago

Oncology·bioRxiv

Somatic Structural Variant Discovery Improves with Tumor-Specific Strings

VESPA-SS detects somatic structural variants from long-read tumor-normal data without initial mapping, outperforming existing callers on cancer cell…

5 days ago

Oncology·STAT

Urothelial Carcinoma Study Finds IL6ST, LIFR, and JAK1 as Top Diagnostic Genes

Transcriptomic analysis in urothelial carcinoma identified IL6ST, LIFR, and JAK1 as strong diagnostic genes tied to immune pathways,…

5 days ago

Oncology·Cancer Cell

ac4C RNA imaging gains sensitivity with fluorine metabolic labeling assay

Researchers developed FMPLA, a sensitive imaging method for ac4C-modified RNA that tracks spatial dynamics, cell-cycle changes, and drug-resistant…

5 days ago

Oncology·Cancer Cell

Colorectal Cancer Drug Resistance Reshaped by Multi-Layered Tumor Networks

A systematic overview explains how colorectal cancer drug resistance emerges through tumor, immune, metabolic, and microbiome networks, guiding…

5 days ago

Oncology·Cancer Cell

sc-rDSeq reveals hidden lung cancer drug resistance at single-cell level

A new full-length single-cell RNA method exposes drug-resistant lung cancer heterogeneity, non-polyA transcripts, splicing changes, and resistance programs.

5 days ago

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.