Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Tau pathology in epilepsy points to new dementia and seizure targets

A neurology review links tau pathology to epilepsy, cognition, and dementia, and examines biomarkers, imaging, and sodium selenate trials.

By Dr. A. Manasa, MBBS · 2 days ago · 5 min read

Neurology·BMJ Open

Nerve Transfer Surgery Trial Targets Upper Limb Recovery in Cervical SCI

BMJ Open protocol details a prospective multicentre study of nerve transfer surgery for acute cervical spinal cord injury…

3 days ago

Neurology·BMJ Open

EMA dossiers expose sex gaps in CNS drug development

A BMJ Open study reviews EMA dossiers from 2012-2022 to assess sex representation and sex-related differences in CNS…

3 days ago

Neurology·Nat Rev Onc

Parkinson disease genetics moves closer to precision medicine

A new review details how Parkinson disease genetics is refining diagnosis, prognosis, risk prediction, and targeted therapy development.

3 days ago

Neurology·Nat Rev Onc

Alzheimer’s single-cell machine learning maps genetically anchored cell programs

TriSCOPE linked single-cell Alzheimer’s signals to inherited risk and cell-type-specific programs across 4.2 million nuclei from 627 donors.

3 days ago

Neurology·Nat Rev Onc

Amyloid-β intermediates linked to Alzheimer’s pathology in new study

Two functionally distinct amyloid-β intermediates were mapped across models and human tissue, linking aggregation routes to toxicity and…

3 days ago

Neurology·medRxiv

Polygenic Dementia Risk Split by Cognitive Reserve and Aging Decline

A 26-year preprint in 11,518 adults separates dementia polygenic effects into premorbid cognition and aging-related decline pathways.

3 days ago

Neurology·bioRxiv

APOE isoforms drive distinct antioxidant responses in aging brain

Humanized mouse and human brain data link APOE isoforms to divergent antioxidant signaling, protein output, and aging-related neurodegenerative…

3 days ago

Neurology·DailyMed

Carbidopa-Levodopa Extended-Release Label Details Parkinson’s Dosing and PK

DailyMed label details for carbidopa and levodopa extended-release tablets cover Parkinson’s indications, release kinetics, geriatric exposure, and contraindications.

3 days ago

Neurology·NLM

Traumatic Brain Injury Hospitalizations Rise in Older Medicare Beneficiaries

A Medicare claims study found traumatic brain injury hospitalizations rose with age, were higher in women, and varied…

3 days ago

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.