Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Tocilizumab and FIRES: Review Examines Long-Term Neurological Recovery

A systematic review and meta-analysis assessed tocilizumab in pediatric FIRES, focusing on long-term neurological recovery after severe neuroinflammation.

By Dr. A. Manasa, MBBS · 17 hrs ago · 5 min read

Neurology·ClinicalTrials

Acoustic Stimulation in Sleep Taps Alzheimer’s Cognitive Recovery Pathway

A randomized sham-controlled trial will test whether closed-loop acoustic stimulation during NREM sleep improves cognition in Alzheimer’s-related mild…

20 hrs ago

Neurology·medRxiv

Alzheimer’s MRI study links tau-vulnerable MTL connectivity to synaptic decline

Resting-state fMRI linked tau-vulnerable medial temporal lobe connectivity to synaptic dysfunction and cognitive decline across Alzheimer’s stages.

21 hrs ago

Neurology·medRxiv

Genome-wide study links early MS disability to TNFSF4, TNFSF18, ADAMTS2

A genome-wide study in early multiple sclerosis identifies replicated loci, effector genes, and pathways tied to early disability…

21 hrs ago

Neurology·medRxiv

Hemorrhagic Stroke Incidence in Japan Shows Sex-Specific Subtype Split

Population data from Japan show higher ICH in men and higher SAH in women, yet overall hemorrhagic stroke…

21 hrs ago

Neurology·bioRxiv

SilencioMA targets MAPT and APP in preclinical Alzheimer’s study

A preclinical preprint describes SilencioMA, a single compound designed to silence MAPT and APP mRNAs and reduce Aβ…

22 hrs ago

Neurology·Becker H

Deep learning detects widespread sleep spindles tied to memory load

Deep learning found widespread multi-area sleep spindles in primate and human recordings, with patterns shifting after a visual…

1 day ago

Neurology·Nature

Retinal imaging tracer detects TDP-43 pathology in ALS and related disease

A fluorescent ocular tracer detected TDP-43 deposits in postmortem retinas from ALS, FTD-TDP-43, and LATE, pointing to a…

1 day ago

Neurology·ScienceDaily

Obesity Linked to Lower Mortality After Dementia Diagnosis

In a 4,523-person cohort, overweight and obesity at dementia diagnosis were linked to 16% to 27% lower mortality,…

1 day ago

Neurology·Med News Today

Brain imaging ARC tool may distinguish Alzheimer’s from SuperAgers

A new fMRI-based scoring tool, ARC, separated SuperAgers from Alzheimer’s disease and may flag brain vulnerability before symptoms…

1 day ago

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.