Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Parkinson’s Cognitive Decline Improved With Intermittent NBM DBS

Five Parkinson’s patients saw clinically meaningful cognitive gains after combined STN and intermittent nucleus basalis DBS in a Stanford feasibility study.

By Dr. A. Manasa, MBBS · Nov 3, 2026 · 6 min read

Neurology·medRxiv

Polygenic Risk Distinguishes Alzheimer’s and Psychiatric Disease in Young-Onset Dementia

In a young-onset dementia cohort, Alzheimer’s and psychiatric polygenic risk separated disease groups but did not track with…

Nov 3, 2026

Neurology·bioRxiv

LRRK2 Parkinson’s variants act through conformation, not just kinase activity

A preprint links most LRRK2 Parkinson’s variants to an unlatching conformation, membrane localization, and reduced S935 phosphorylation.

Nov 3, 2026

Neurology·Nat Rev Neuro

Speech Data Predicts Fatigue in Shift Workers, Longitudinal Study Finds

A 1,197-person longitudinal study found speech features could track sleepiness and deeper fatigue in shift workers with low-burden,…

Nov 3, 2026

Neurology·BMJ

Huntington’s Disease MRI Volumetry: FreeSurfer vs IXIQ.Ai Comparison

JNNP abstract examines MRI volumetric segmentation in Huntington’s disease, comparing FreeSurfer with IXIQ.Ai for automated brain structure analysis.

Nov 3, 2026

Neurology·BMJ

Huntington’s Disease Research Engagement Barriers Examined in Ireland

An Irish Huntington’s disease abstract examines why patients engage with research and what barriers shape participation, though the…

Nov 3, 2026

Neurology·Nature

Environmental Risk Factors in Lewy Body Dementia Vary by Sex

A remote pilot study in Lewy body dementia linked metal exposure, smoking, alcohol, and household chemicals to higher…

Nov 3, 2026

Neurology·ScienceDaily

Alzheimer’s Drug KCL-286 Repairs DNA Damage in Mouse Study

KCL-286 repaired DNA damage and reduced inflammation in an Alzheimer’s mouse model, with prior Phase 1 human safety…

Nov 3, 2026

Neurology·MHRA

Dementia clinical nurse specialist role expands memory service assessment in Harrow

A Harrow NHS post seeks a dementia clinical nurse specialist to lead cognitive assessment, diagnostic formulation, and memory…

Nov 3, 2026

Neurology·JCI

Spinal Muscular Atrophy Immune Study Cannot Be Rewritten From Incomplete Source

The scraped JCI item lacks methods, results, and discussion, so no factual clinical rewrite of the spinal muscular…

Nov 3, 2026

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.