Neurology

From stroke to neurodegeneration — the science and its clinical impact.

MAP1S Phosphorylation Controls Dynein Transport in Neurons

CDKL5-linked MAP1S phosphorylation governs dynein transport, AMPA receptor trafficking, and synapse formation in neurons, with CDD-relevant behavioral deficits.

By Dr. A. Manasa, MBBS · Nov 3, 2026 · 5 min read

Neurology·ScienceDaily

Liver Rejuvenation Drug Cuts Amyloid Beta and LDL in Rats

An experimental drug restored aging liver cells in rats, halved amyloid beta, normalized LDL, and revealed a new…

Nov 3, 2026

Neurology·NLM Alerts

Preclinical Alzheimer’s Prognostic Models Cut Trial Sample Size

A multimodal prognostic model using pTau217, MRI, and tau PET predicted decline in preclinical Alzheimer’s disease and improved…

Nov 3, 2026

Neurology·NIH

Delirium Linked to Long-Term Cognitive Trajectories in Mayo Aging Cohort

Mayo Clinic cohort study examines whether delirium during hospitalization predicts later MCI, dementia, and long-term cognitive decline.

Nov 3, 2026

Neurology·Nature

BDNF in Adolescent Athletes Varies by Sex, Height and Sport Type

Plasma BDNF in adolescent athletes was higher in males, lower in contact sports, and influenced by height and…

Nov 3, 2026

Neurology·ACC-PRO

Parkinson’s Disease Psychosis Treatment: Pimavanserin, Clozapine, and Care Gaps

Updated review of Parkinson’s disease psychosis treatment covers triggers, medication adjustment, and the strongest evidence for pimavanserin and…

Nov 3, 2026

Neurology·JCI

EpiPred flags likely pathogenic STXBP1 variants in epilepsy genetics

A gene-specific machine learning model, EpiPred, helps identify likely pathogenic variants in STXBP1, a key epilepsy-related gene.

Nov 3, 2026

Neurology·JCI

TMEM175 Mutation Links Lysosomal Acidification to Parkinson’s Disease Pathology

A rare TMEM175 mutation appears to worsen Parkinson’s disease by impairing proton gating and lysosomal acidification, pointing to…

Nov 3, 2026

Neurology·NIH

Depression Linked to Disrupted Neurogenesis in the Hippocampus

NIH-funded research in 30 brain donors links depression with stalled hippocampal neuron maturation and altered gene activity tied…

Nov 3, 2026

Neurology·JCI

SMN restoration in SMA may leave immune defects unresolved

A JCI commentary examines immune-cell SMN deficits in treated spinal muscular atrophy and why motor recovery may not…

Nov 3, 2026

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.