Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Hydroxyzine-based lipid nanoparticles boost brain RNA delivery in preclinical study

A hydroxyzine-derived lipid nanoparticle delivered mRNA and gene-editing cargo to the brain in mice and a non-human primate, with radioprotection data.

By Dr. A. Manasa, MBBS · Nov 4, 2026 · 5 min read

Neurology·Br J Cancer

NO and whole-body vibrations increase brain protein efflux in adults

In 29 healthy adults, sublingual nitric oxide plus whole-body vibration increased circulating brain proteins and altered neurofluid imaging…

Nov 4, 2026

Neurology·Cancer Cell

Sleep ripples split into subtypes tied to memory consolidation in rats

Rat sleep study maps hippocampal ripple subtypes and links their cortical coordination to simple versus complex memory consolidation.

Nov 4, 2026

Neurology·PNAS

Melanopsin expression boosts retinal ganglion cell axon regeneration via cAMP and TRPC

Ectopic melanopsin expression enhanced retinal ganglion cell axon regeneration after optic nerve crush through linked TRPC and cAMP…

Nov 4, 2026

Neurology·JCI

Spinal Muscular Atrophy Study Links SMN Deficits to Immune Cell Changes

JCI research finds cell-specific SMN loss and persistent immune alterations in treated spinal muscular atrophy, including shifts in…

Nov 4, 2026

Neurology·JCI

Single AAV base editing restores dystrophin in humanized DMD mice

A compact MyoAAV base-editing system restored dystrophin in humanized DMD mice while sparing the liver and reducing muscle…

Nov 4, 2026

Neurology·Nature

Parkinson’s RBD Outperforms Imaging in Brain-First vs Body-First Sorting

Probable REM-sleep behavior disorder correctly classified most early Parkinson’s cases in a small study, while other markers showed…

Nov 4, 2026

Neurology·BBC Dental

Jersey neurology staffing crisis leaves 1,197 patients waiting

Jersey’s neurology service faces a severe staffing shortage, with 1,197 patients waiting for first appointments and recruitment still…

Nov 4, 2026

Neurology·BBC Dental

Friedreich’s Ataxia Drug Access Fight Reaches Downing Street

A teenager with Friedreich's ataxia has asked for NHS access to omaveloxolone as UK drug talks stall and…

Nov 4, 2026

Neurology·ScienceDaily

Fear, PTSD, and the brain’s hidden safety-danger overlap

Mouse imaging study in Nature Neuroscience suggests fear blurs safety and danger maps in the ventral hippocampus, a…

Nov 4, 2026

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.