Neurology

From stroke to neurodegeneration — the science and its clinical impact.

NAD+ Precursor Fails to Improve Parkinson’s Disease in Large Trial

A 410-participant randomized trial found no clinical benefit from nicotinamide riboside in early Parkinson’s disease after 1 year of treatment.

Parents of children with monogenic neurodevelopmental disorders weigh hope against concerns that novel treatments could alter identity and…

Single-cell Mendelian randomization tied immune cell-specific gene expression to Alzheimer’s risk, with TNF in CD4+SOX4+ T cells emerging…

A large MRI cohort links a new para-ISS dural enhancement sign to intracranial atherosclerotic burden, with graded associations…

A first-in-human case study links chronic 55 Hz motor thalamus DBS to durable gains in speech, swallowing, and…

BMJ Open protocol will review phosphodiesterase-3 inhibitors for cerebral vasospasm after aneurysmal subarachnoid hemorrhage in ICU patients.

Patient and mouse data tie cellular senescence to FSHD progression and show lamivudine reduced senescence, inflammation, and fibrosis.

JAMA Network Open corrected missing conflict disclosures and clarified that icometrix makes the icobrain aria tool in an…

ARIC data show a spouse’s traumatic brain injury was tied to modestly higher mortality in the uninjured partner,…

A PLOS ONE study used pose estimation and machine learning to quantify gait coupling in Parkinson’s disease and…

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds