Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Parkinson’s Disease Biomarkers Linked to Mitochondrial Dynamics in GEO Study

GEO-based analysis identified CYSLTR2 and TTPAL as candidate Parkinson’s disease biomarkers tied to mitochondrial dynamics dysfunction and immune signals.

By Dr. A. Manasa, MBBS · Nov 6, 2026 · 5 min read

Neurology·PLOS ONE

PDD model links acetylcholine loss to cortical rhythm disruption

A computational PDD model links acetylcholine loss in the PPN to cortical rhythm changes and a synergy with…

Nov 6, 2026

Neurology·PLOS ONE

Stroke study monitoring protocol builds independent oversight for India cohort

A PLOS One protocol outlines independent monitoring for the NIMHANS–NH–SKAN Stroke project, using checklists, KPIs, and multi-domain oversight.

Nov 6, 2026

Neurology·medRxiv

CSF PrP-amyloid seeding predicts onset in inherited prion disease

Longitudinal CSF RT-QuIC testing identified near-term clinical conversion in PRNP E200K carriers, with first positivity appearing years before…

Nov 5, 2026

Neurology·medRxiv

Plasma GFAP Tracks Amyloid and Tau Stage in Alzheimer Disease

Plasma GFAP mediated amyloid and tau biomarker links in two Alzheimer cohorts, with stage-specific patterns and proteomic signals…

Nov 5, 2026

Neurology·medRxiv

Machine Learning DTI Biomarker Improves Epilepsy Lateralization

Elastic net analysis of DTI white matter features classified epilepsy lateralization with AUCs up to 0.88 in a…

Nov 5, 2026

Neurology·medRxiv

Alzheimer’s Genetic Risk Maps to Microglial and Proteopathic Pathways

A preprint maps 127 Alzheimer’s risk loci to microglial and proteopathic pathways, with tissue-specific targets and druggable genes…

Nov 5, 2026

Neurology·KFF

Muscular Dystrophy Drug Fails in Trial After Costly Development Gamble

An experimental muscular dystrophy drug failed in trial, dealing a setback to a costly development effort and to…

Nov 5, 2026

Neurology·AHA

AHA to Honor Bruce Ovbiagele with 2026 Braunwald Mentorship Award

The American Heart Association will honor stroke neurologist Bruce Ovbiagele for mentorship, research leadership, and equity-focused training at…

Nov 5, 2026

Neurology·Cancer Cell

Microglial GRB2 variants linked to congenital hydrocephalus and CSF dysregulation

Damaging GRB2 variants in microglia were tied to congenital hydrocephalus, severe ventriculomegaly, and disrupted cerebrospinal fluid homeostasis.

Nov 5, 2026

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.