Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Delayed Lung Cancer Diagnosis After Incidental Nodule Prompts NHS Action

An inquest found a one-year delay in diagnosing lung cancer after an incidental nodule was missed, prompting new patient safety action at NUH.

By Dr. Revathy Mohan V.R., MBBS · Oct 28, 2026 · 5 min read

Oncology·Nature

Extramedullary Myeloma Shows Immune-Excluded Tumor Microenvironment

Spatial profiling of extramedullary multiple myeloma found immune-cell separation, inhibitory checkpoint expression, and a suppressive niche tied to…

Oct 28, 2026

Oncology·Nature

PROTEUS trial supports neoadjuvant apalutamide in high-risk prostate cancer

PROTEUS found benefit for neoadjuvant systemic therapy with apalutamide plus ADT in high-risk localized or locally advanced prostate…

Oct 28, 2026

Oncology·NIH

HTR2A Variants Linked to Breast Cancer Risk in African American Women

HTR2A variants and dysregulated miRNAs were associated with breast cancer risk in African American women, with implications for…

Oct 28, 2026

Oncology·Nat Rev Onc

Cancer research manifesto calls for routine inclusion of older adults

A Nature Reviews manifesto argues older adults must be systematically included in cancer research from prevention through end-of-life…

Oct 28, 2026

Oncology·BMJ Open

Implementation science protocol targets global pediatric oncology survival gap

BMJ Open protocol maps implementation science in global pediatric oncology to identify barriers, gaps, and scale-up strategies across…

Oct 28, 2026

Oncology·Front Immunol

SPP1 drives anoikis resistance and metastasis in hepatocellular carcinoma

SPP1 promoted anoikis resistance, migration, and pulmonary colonization in hepatocellular carcinoma, while circulating OPN tracked with aggressive disease.

Oct 28, 2026

Oncology·J Hepatology

Locoregional therapies in cholangiocarcinoma gain a defined role in selected patients

A Journal of Hepatology review finds locoregional therapies can extend control in cholangiocarcinoma, especially when paired with systemic…

Oct 27, 2026

Oncology·Cancer Disc

Mechanical Stress Triggers Nuclear Envelope Rupture in Melanoma Cells

A melanoma study points to mechanical stress-driven nuclear envelope rupture as a mechanism that may reshape tumor-stromal interactions.

Oct 27, 2026

Oncology·Cancer Disc

Spatial Transcriptomics Finds Race-Related Differences in Pancreatic Cancer

Spatial transcriptomics in a diverse pancreatic cancer cohort points to race-related differences in tumor subtypes and immune microenvironments.

Oct 27, 2026

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.