Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Basophils May Block Early Lung Metastasis Through Treg Suppression

Basophils suppressed early lung metastasis in mice, and loratadine increased circulating Treg cells in a crossover trial of healthy volunteers.

By Dr. Revathy Mohan V.R., MBBS · Nov 4, 2026 · 5 min read

Oncology·Br J Cancer

SER-155 lowered bloodstream infections after allogeneic transplant in phase 1b trial

In a phase 1b transplant study, the oral live biotherapeutic SER-155 reduced bloodstream infections versus placebo and was…

Nov 4, 2026

Oncology·Br J Cancer

CAR T therapy linked to clonal hematopoiesis and prolonged cytopenias

CAR T therapy may leave a hematologic legacy: clonal hematopoiesis in inflamed marrow is tied to prolonged cytopenias…

Nov 4, 2026

Oncology·Br J Cancer

Virginia Tech Seeks Clinical Cancer Research Faculty for Roanoke Campus

Virginia Tech is recruiting a physician-scientist for clinical cancer research at its Roanoke biomedical campus with federal-grade infrastructure…

Nov 4, 2026

Oncology·Br J Cancer

Proton Therapy Energy Optimization for Hodgkin’s Lymphoma in Monte Carlo Study

A Monte Carlo study in Hodgkin’s lymphoma identifies 70 MeV as the best fit for a 5–42 mm…

Nov 4, 2026

Oncology·Nat Rev Neuro

TIL therapy with regulatable IL-15 shows early activity in melanoma

Amsokigene autoleucel showed manageable safety and early response signals in checkpoint inhibitor-resistant advanced melanoma across pooled phase 1…

Nov 4, 2026

Oncology·Nat Rev Neuro

TNKS2 Inhibitor May Enable Tumor-Restricted WNT Suppression

A first-in-class TNKS2 inhibitor selectively suppressed WNT signaling in TNKS1-deficient cancer models, pointing to a tumor-restricted therapeutic strategy.

Nov 4, 2026

Oncology·Cancer Cell

GClnc1 in Human Cancers: Oncogenic Mechanisms and Clinical Implications

Cell Press review examines GClnc1 as an oncogenic long noncoding RNA, with mechanistic roles and possible clinical relevance…

Nov 4, 2026

Oncology·JCI

Belumosudil may help overcome KRAS resistance in pancreatic cancer models

Early pancreatic cancer models suggest the ROCK2 inhibitor belumosudil may counter resistance to KRAS inhibition, a key hurdle…

Nov 4, 2026

Oncology·JCI

NAT10 inhibition boosts anti-PD-1 response in murine lung tumors

In murine lung tumors, NAT10 inhibition reprogrammed Tregs, lowered PD-1+ Treg burden, and improved anti-PD-1 tumor control.

Nov 4, 2026

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.