Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Checkpoint Blockade in HIV-Negative Kaposi Sarcoma: Biomarker Limits

A Frontiers review finds limited direct evidence for PD-1 blockade in HIV-negative Kaposi sarcoma and rejects PD-L1 or KSHV DNA as stand-alone tests.

Ifupinostat produced responses in relapsed or refractory DLBCL after multiple prior therapies, with rapid onset and substantial hematologic…

Low WASL expression tracked with longer survival in pancreatic ductal adenocarcinoma, and pancreas-specific Wasl deletion slowed tumor progression…

FBXW5 suppresses RNA-sensing and type I interferon signaling in triple-negative breast cancer, shaping a cold tumor microenvironment and…

In a target trial emulation, SSRI use was linked to lower mortality and more thyroid irAEs than benzodiazepines…

ASCI awards the 2026 Harrington Prize to Arul Chinnaiyan and Charles Sawyers for discoveries that defined prostate cancer…

A multicenter retinoblastoma study explores liquid biopsy for extraocular spread, treatment response, and recurrence risk without reported outcome…

HLX11 matched reference pertuzumab in a phase 3 neoadjuvant breast cancer trial, with similar pathological complete response, safety,…

ACKR3 has been identified as a squamous-restricted immune checkpoint axis in lung squamous cell carcinoma, pointing to a…

BI-1808, an anti-TNFR2 antibody, produced tumor regression and antitumor T cell immunity in solid tumors through Treg and…

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds