Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Prodromal alpha-synuclein disease linked to lower verbal memory

Prodromal neuronal alpha-synuclein disease showed modest verbal-memory loss and rising mild cognitive impairment odds, while other domains stayed intact.

By Dr. A. Manasa, MBBS · 5 days ago · 5 min read

Neurology·bioRxiv

Intestinal alpha-synuclein SAA detects Parkinson’s pathology better than IHC

Intestinal mucosal seed amplification assay detected alpha-synuclein aggregates more often than IHC in Parkinson’s disease and showed region-specific…

5 days ago

Neurology·bioRxiv

EEG Foundation Model Attention Maps Enable Lightweight Emotion Recognition

A preprint shows EEG foundation model attention maps can support interpretable emotion recognition with far fewer calculations than…

5 days ago

Neurology·bioRxiv

Microglial AhR linked to sex-biased amyloid pathology in Alzheimer’s model

A preprint links microglial AhR signaling to worse amyloid pathology, with sex-dependent effects and protection after AhR loss…

5 days ago

Neurology·bioRxiv

Dual-band vibration may improve anti-kindling in Parkinson’s network model

A spiking network model found that phase-locked dual-band vibrotactile bursts produced the strongest anti-kindling and lowest coupling among…

5 days ago

Neurology·STAT

Alzheimer’s disease review maps immune modulation as a therapeutic strategy

A 2025 review in Molecular Neurodegeneration outlines immune pathways in Alzheimer’s disease and reviews immunomodulatory therapies in development.

5 days ago

Neurology·ScienceDaily

High-dose flu shot tied to lower Alzheimer’s risk in older adults

Nearly 200,000 adults 65 and older were studied, and high-dose influenza vaccination was linked to a lower Alzheimer’s…

5 days ago

Neurology·ScienceDaily

Rapamycin Improves Brain Blood Flow in APOE4 Carriers

A pilot trial found low-dose rapamycin improved cerebral blood flow in healthy middle-aged APOE4 carriers, with the largest…

5 days ago

Neurology·ScienceDaily

Alzheimer’s Tau Linked to Lonely Slow Waves and Memory Loss

UC Berkeley researchers linked frontal tau buildup to fragmented deep-sleep slow waves and weaker overnight memory in older…

5 days ago

Neurology·Nature

Branched-Chain Amino Acids Linked to Lower Parkinson’s Risk in UK Biobank

In UK Biobank, higher circulating branched-chain amino acids were linked to lower incident Parkinson’s risk and prediagnostic biomarker…

5 days ago

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.