Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Brain Somatic Mosaicism May Link Development, Ageing and Neurodegeneration

A Nature Reviews Neurology review describes how brain somatic mosaicism shapes development, epilepsy, ageing and neurodegeneration across cell types.

Nature Reviews Neurology outlines atypical Alzheimer disease as a biologically defined but clinically diverse disorder shaped by regional…

A phase III trial of obinutuzumab β showed striking efficacy in aquaporin-4-IgG-positive NMOSD, sharpening questions about depth of…

A medRxiv preprint links biallelic BECN1 variants to neurodevelopmental disorders through AMPA receptor dysregulation, pointing to a synaptic…

Mouse study links TLR4 signaling to central and peripheral autoimmune inflammation, with TAK-242 reducing EAE severity, demyelination, and…

Two women with inflammatory CSF and negative microbiology were ultimately diagnosed with GFAP astrocytopathy after presenting like infectious…

Autopsy and imaging in a TREM2 p.R47H carrier linked aducanumab-associated amyloid clearance with less tau pathology and slower…

A 2026 review examines extracellular vesicles in ischemic stroke, from neuroprotection and BBB delivery to biomarker use and…

The LIGHT trial will test whether coaching, vouchers, and self-management can reduce modifiable dementia risk in memory clinic…

Researchers derived and validated electronic health record measures to characterize the inpatient sleep experience and inform better hospital…

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds