Neurology

From stroke to neurodegeneration — the science and its clinical impact.

TMEM63B links dorsal root ganglia to noxious heat sensation

TMEM63B in dorsal root ganglia reduced heat sensitivity when deleted and showed lipid-dependent heat activation, pointing to a new nociceptive pathway.

By Dr. A. Manasa, MBBS · Oct 20, 2026 · 5 min read

Neurology·Sci Transl Med

Mitochondrial Carbonic Anhydrase-VB Inhibition Improves Memory in Alzheimer Models

Preclinical work links mitochondrial carbonic anhydrase-VB inhibition to reduced brain endothelial stress and better memory in Alzheimer’s disease…

Oct 20, 2026

Neurology·Gut

Gut microbiome signatures track autism severity in children

A multi-omics study links gut microbiome shifts, especially Clostridioides difficile, to autism severity and brain structure in young…

Oct 20, 2026

Neurology·Nature

IGFBP5 Knockdown Improves Early Nerve Regeneration After Sciatic Injury

Mouse data link IGFBP5 knockdown to stronger early neurovascular repair, less oxidative stress, and better motor recovery after…

Oct 20, 2026

Neurology·Nature

SynthSR MRI harmonization shows limits for hippocampal volume in autoimmune disease

SynthSR harmonized heterogeneous brain MRI in autoimmune encephalitis, but overestimated hippocampal volume and was unreliable for individual patients.

Oct 20, 2026

Neurology·ScienceDaily

Aging Brain May Shift From Memory to Meaning, Researchers Say

Researchers propose that healthy brain aging may favor meaning, wisdom, and social knowledge over detailed episodic memory, distinct…

Oct 20, 2026

Neurology·ScienceDaily

Alzheimer’s Brain Damage Falls With CXCR3 Blockade in Mice

Blocking CXCR3 cut T-cell entry into mouse brains, preserved memory-region tissue, and improved memory despite unchanged tau tangles.

Oct 20, 2026

Neurology·MHRA

AI DeepSUVR improves amyloid PET Centiloid quantification across studies

DeepSUVR improved Centiloid amyloid PET consistency across tracers, strengthened links to cognition and pathology, and sharpened treatment-effect detection.

Oct 20, 2026

Neurology·PNAS

Gerstmann-Sträussler-Scheinker Disease Prion Deposits in Indiana Kindred

PNAS report on prion protein preamyloid and amyloid deposits in the Indiana kindred of Gerstmann-Sträussler-Scheinker disease.

Oct 20, 2026

Neurology·NIH

Serum Lipids Link to Alzheimer Biomarkers in ADNI-1 Study

ADNI-1 data linked one serum phosphatidylcholine and SHBG with Alzheimer group status, while Aβ42 signals shifted across statistical…

Oct 20, 2026

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.