Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Social activity linked to slower cognitive decline in older adults

Across 24 countries, older adults with broader social activity patterns had slower cognitive decline, with volunteering and sports clubs most consistent.

By Dr. A. Manasa, MBBS · Oct 27, 2026 · 5 min read

Neurology·ScienceDaily

Alzheimer’s Cognitive Resilience Linked to Immature Neurons in Aging Brain

Immature neurons persisted in brains over 80 and showed different survival signals in cognitively resilient Alzheimer’s cases, pointing…

Oct 27, 2026

Neurology·CMAJ

Stroke rehabilitation may need to measure perceived effort, not just motor recovery

An opinion paper argues that perceived effort, shaped by fatigue and pain, should become a clinical marker in…

Oct 27, 2026

Neurology·BBC Dental

Young Stroke Survivor Defies Prognosis After Brain Bleed

A 29-year-old dancer survived a severe brain bleed after two emergency operations and is relearning speech, walking, and…

Oct 27, 2026

Neurology·NIH

Tofersen and ALS: Regulatory Update and Nanotherapeutic Strategies

A focused review of tofersen’s SOD1-targeted approval, ALS regulatory updates, and emerging nanotherapeutic approaches for rare disease care.

Oct 27, 2026

Neurology·Nature

Treg instability linked to BBB disruption in perioperative neurocognitive disorders

Single-cell profiling and mouse data tie perioperative Treg instability to blood-brain barrier disruption and cognitive decline through β-catenin…

Oct 27, 2026

Neurology·BMJ

Spreading depolarization emerges as a neuroprotection target in cerebral ischemia

Spreading depolarization marks the final reversible phase before ischemic neuronal death and may guide neuroprotection across acute brain…

Oct 27, 2026

Neurology·medRxiv

Ultra-Low-Field MRI Can Build Reliable Brain Network Maps, Study Finds

Ultra-low-field MRI generated reliable morphometric brain networks, with MIND and MSN methods each excelling for different analytic goals…

Oct 27, 2026

Neurology·medRxiv

Lesion Network Mapping Artifact Tied to Lesion Size in Preprint

A medRxiv preprint argues lesion extent can distort lesion network mapping by diluting focal signals and biasing maps…

Oct 26, 2026

Neurology·medRxiv

fMRI Detects Reversible Motor Network Changes in Suspected TIA

A pilot fMRI study found transient motor-network suppression in suspected TIA, with partial normalization at 3 months and…

Oct 26, 2026

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.