Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Down syndrome and Alzheimer’s disease diagnosed earlier in England study

Real-world data from England show Alzheimer’s disease is diagnosed decades earlier in people with Down syndrome, with distinct comorbidity patterns.

By Dr. A. Manasa, MBBS · Oct 28, 2026 · 5 min read

Neurology·JNCI

Medication Confounders in Brain Death Determination: Opioids as Example

A primer on medication confounders before brain death determination, using opioids to frame bedside assessment, exclusion steps, and…

Oct 28, 2026

Neurology·JNCI

Insomnia Disorder Brain Network Study Examines Structural and Functional Abnormalities

A JNCI-linked Oxford Academic abstract examines how insomnia disorder may involve heterogeneous structural and functional brain network abnormalities.

Oct 28, 2026

Neurology·NLM Alerts

Tea Catechins and Microbial Metabolites in Parkinson’s Disease Seeding

NIH abstract examines how tea catechins and gut microbial metabolites may modulate gut-origin alpha-synuclein seeding in Parkinson’s disease.

Oct 28, 2026

Neurology·Nat Rev Neuro

KARI dataset expands preclinical Alzheimer imaging across 1,645 participants

The Knight Alzheimer Research Imaging dataset links MRI, PET, cognition, genetics, and biomarkers across the Alzheimer spectrum in…

Oct 28, 2026

Neurology·Br J Cancer

ABCA1 Cholesterol Pathway Linked to Parkinson’s Neurodegeneration

ABCA1-driven cholesterol trafficking promoted neuronal damage in Parkinson’s models, and magnesium citrate reduced dopaminergic loss in mice.

Oct 28, 2026

Neurology·Br J Cancer

Multi-organ imaging genetics reframes brain disease as a whole-body problem

A new roadmap for multi-organ imaging genetics links brain disease to heart, retina and other organs, with AI…

Oct 28, 2026

Neurology·medRxiv

Chinese PPA study finds syntax deficits across all variants

Chinese PPA patients showed broad sentence comprehension and production deficits, with syntax and lexical features shaping performance across…

Oct 28, 2026

Neurology·ScienceDaily

Autistic Brain Face Processing Differs Earlier Than Thought

A Yale-led EEG study found autistic children show less specialized face processing, with developmental differences emerging earlier than…

Oct 28, 2026

Neurology·Nature

Duchenne Gene Therapy Trial Linked to Death Shows Limited Efficacy

First human trial of an experimental Duchenne gene-editing therapy showed limited benefit and a fatal immune reaction after…

Oct 28, 2026

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.