Immunology

Clinical evidence, research, and medical intelligence in Immunology.

mRNA Splicing Connects Surface Immunity and NLR Activation in Plants

A mechanistic abstract describes how mRNA splicing may connect surface immunity to NLR activation, with implications for crop disease resistance.

By Dr. A. Nikhil Krishnan, MBBS · Oct 25, 2026 · 5 min read

Immunology·Front Immunol

Mitochondrial stress links ultrafine particles and nanoplastic immunotoxicity

New research links ultrafine particulate matter, black carbon, and polystyrene nanoplastics to shared and particle-specific mitochondrial stress responses.

Oct 25, 2026

Immunology·Front Immunol

Rubicon Loss Weakens Gut Barrier and Worsens Salmonella Infection

Mouse data show Rubicon helps preserve intestinal barrier integrity, limits permeability, and protects against Salmonella dissemination.

Oct 25, 2026

Immunology·bioRxiv

TCR Antigen Prediction Faces Bias and Generalisability Barriers

A bioRxiv preprint examines why TCR–antigen prediction models fail to generalise and calls for better data curation and…

Oct 25, 2026

Immunology·Front Immunol

cDC1 Expansion from Human PBMCs May Advance DC-Based Cancer Vaccines

A two-step PBMC protocol generated functional XCR1+CD141+ cDC1 cells, boosted CTL activity, and showed no treatment-related toxicity in…

Oct 24, 2026

Immunology·ACC-PRO

Gilead pays $1.3B for oral IL-23 challenger HCXT-2001

Gilead is acquiring PepStar’s oral IL-23 receptor inhibitor HCXT-2001, a phase 1 asset aimed at competing in inflammatory…

Oct 24, 2026

Immunology·Nature

COVID-19 Immune Responses Remain Altered 2 Years After Critical Illness

Two years after critical COVID-19, ex vivo cytokine responses remained elevated and linked to age and innate immune…

Oct 24, 2026

Immunology·Cancer Cell

LDHA Controls Redox-Driven mRNA Translation in Monocyte Fate Commitment

Cell Press study links LDHA-dependent redox control to selective mRNA translation, defining a mechanism that guides monocyte fate…

Oct 24, 2026

Immunology·Front Immunol

NLRP3 Inflammasome Gains Attention in Sjögren Disease

A review links NLRP3 inflammasome dysregulation to Sjögren disease activity, glandular injury, systemic phenotypes, and therapeutic targets.

Oct 23, 2026

Immunology·bioRxiv

Single-cell immune cell contact profiling refines tuberculosis interaction signals

Image-guided sorting separated true T cell-monocyte contacts from coincidental doublets, revealing distinct transcriptional programs in tuberculosis.

Oct 23, 2026

Immunology

Clinical evidence, research, and medical intelligence in Immunology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.