Endocrinology

Trials, guidelines and clinical evidence across Endocrinology.

Circadian Misalignment Links Obesity to Inflammation and Gut Barrier Changes

Human obesity study links circadian misalignment with inflammation, gut barrier disruption, and microbiome shifts, pointing to a time-based metabolic mechanism.

By Dr. A. Nikhil Krishnan, MBBS · Oct 21, 2026 · 4 min read

Endocrinology·Nat Rev Neuro

Time-restricted eating and exercise did not lower liver fat in obesity trial

In a 12-week randomized trial, time-restricted eating, exercise, or both failed to beat usual care for reducing intrahepatic…

Oct 21, 2026

Endocrinology·Br J Cancer

Brown Fat Study Expands Links to Cardiometabolic Health Benefits

A large study broadened evidence that brown fat may be tied to multiple health benefits, strengthening interest in…

Oct 21, 2026

Endocrinology·Br J Cancer

Brown fat linked to lower diabetes, depression and anxiety risk in massive study

A study of more than 100,000 people links active brown fat to lower rates of type 2 diabetes,…

Oct 21, 2026

Endocrinology·Br J Cancer

AI maps human brown fat links to lower cardiometabolic and psychiatric disease

Artificial intelligence analysis of 101,243 patients links brown fat to lower cardiometabolic and psychiatric disease and supports losartan…

Oct 21, 2026

Endocrinology·Br J Cancer

Digital GLP-1 Therapy in Women Delivers Large Real-World Weight Loss

An observational UK digital care study in 8,127 women found large mean weight loss with mostly tirzepatide, supported…

Oct 21, 2026

Endocrinology·Endocrine

Hypophosphatasia Recognition Depends on Timing, Low ALP, and Family Clues

Endocrine News spotlights hypophosphatasia, where low alkaline phosphatase, genetic testing, and family follow-up can prevent years of missed…

Oct 21, 2026

Endocrinology·Med News Today

Ultra-Processed Foods Trigger Higher Insulin Response in New Study

A Virginia Tech study found ultra-processed meals raised insulin more than less processed meals with similar nutrients in…

Oct 20, 2026

Endocrinology·BMJ Open

Hyperuricaemia Risk Model Flags Renal Failure in New Type 2 Diabetes

A multicentre machine learning study links predicted hyperuricaemia with later kidney failure and mortality in newly diagnosed type…

Oct 20, 2026

Endocrinology·PLOS Med

Mitochondrial interventions in older adults with type 2 diabetes: PLOS protocol

PLOS protocol outlines a systematic review and network meta-analysis of mitochondrial-targeted interventions for older adults with type 2…

Oct 20, 2026

Endocrinology

Trials, guidelines and clinical evidence across Endocrinology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.