Rheumatology

Trials, guidelines and clinical evidence across Rheumatology.

Early British Arthritis Cases May Point to Rheumatoid Arthritis Before 1876

Historical British case descriptions before 1876 are examined for features consistent with rheumatoid arthritis, raising questions about disease recognition.

By Dr. A. Nikhil Krishnan, MBBS · Nov 3, 2026 · 5 min read

Rheumatology·ARD

Mavrilimumab Cuts Inflammation and Neoangiogenesis in Ex Vivo Study

Ex vivo work found GM-CSF receptor α blockade with mavrilimumab reduced infiltrating cells, inflammatory markers and neoangiogenesis.

Nov 2, 2026

Rheumatology·NLM Alerts

SLE core outcome set review identifies 25 candidate domains

A scoping review screened 4,063 studies and distilled 25 candidate domains for the OMERACT systemic lupus erythematosus core…

Nov 2, 2026

Rheumatology·JNCI

B Cell Depletion in Lupus: Patient Selection, Timing and New Therapies

A rheumatology review examines B cell depletion in systemic lupus erythematosus, from anti-CD20 therapy to CAR T cells…

Nov 2, 2026

Rheumatology·EHJ

JAK Inhibitor Discontinuation in Rheumatoid Arthritis: ANSWER Cohort Study

The ANSWER cohort study examined reasons-stratified treatment retention after JAK inhibitor discontinuation in rheumatoid arthritis.

Nov 2, 2026

Rheumatology·ARD

EULAR updates methods for rheumatic disease recommendations and points to consider

EULAR has updated its standard operating procedures for developing rheumatic disease recommendations, centering evidence, consensus, patient input, and…

Nov 1, 2026

Rheumatology·Nature

Seronegative Rheumatoid Arthritis Needs Earlier Risk Stratification

Seronegative rheumatoid arthritis may follow a distinct disease course, with limited biomarkers, different symptoms, and a narrower window…

Nov 1, 2026

Rheumatology·Nature

IgA Vasculitis Genetics Points to Myeloid IgA Signaling Pathway

Genome-wide analysis of 8,098 people identifies FCAR and INPP5D as major IgA vasculitis risk loci, with implications for…

Oct 31, 2026

Rheumatology·Nature

COVID-19 linked to higher incidence of treatment-requiring autoimmune rheumatic disease

A large matched Japanese cohort found COVID-19 was associated with higher 1-year incidence of treatment-requiring autoimmune rheumatic disease…

Oct 30, 2026

Rheumatology·Nature

Gut-Muscle-Joint Axis Reframes Osteoarthritis as a Systemic Disorder

Nature review describes the gut-muscle-joint axis in osteoarthritis, linking dysbiosis, inflammation, sarcopenia, and joint degeneration.

Oct 30, 2026

Rheumatology

Trials, guidelines and clinical evidence across Rheumatology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.