Pulmonology

Trials, guidelines and clinical evidence across Pulmonology.

Tezepelumab reshapes airway epithelial signaling in uncontrolled asthma

Tezepelumab altered epithelial inflammatory transcription and reduced TGF-β2 signaling to smooth muscle cells in uncontrolled asthma.

By Dr. A. Nikhil Krishnan, MBBS · Oct 19, 2026 · 5 min read

Pulmonology·JCI

Macropinocytosis inhibition reduces profibrotic signaling in lung fibrosis models

Experimental lung fibrosis work links macropinocytosis blockade to weaker profibrotic responses in fibroblasts and preclinical pulmonary fibrosis models.

Oct 19, 2026

Pulmonology·JAMA Open

AATD Testing and Treatment Remain Rare in COPD and Asthma Cohort

Veterans Health Administration data found very low α1-antitrypsin deficiency testing and augmentation therapy, with access and demographic gaps…

Oct 18, 2026

Pulmonology·ScienceDaily

Semaglutide linked to fewer asthma attacks in large real-world study

Semaglutide was linked to nearly 40% fewer asthma attacks and fewer COPD flare-ups in a large UK real-world…

Oct 18, 2026

Pulmonology·STAT

MGRN1 Restores Mitochondrial Function in Obesity-Related Acute Lung Injury

MGRN1 overexpression eased obesity-related acute lung injury in mice and lung epithelial cells by restoring mitochondrial function and…

Oct 17, 2026

Pulmonology·STAT

Machine Learning Predicts Functional Status and Costs in PAH

A retrospective PAH cohort study tested six machine learning models to forecast functional class and estimate linked health…

Oct 17, 2026

Pulmonology·Harvard Health

Pneumonia Symptoms Can Be Vague, Especially in Older Adults

Pneumonia can begin with subtle fatigue, confusion, or mild cough. Recognizing early warning signs can speed diagnosis and…

Oct 16, 2026

Pulmonology·MedlinePlus

Asthma Microbiome Study Examines Environmental Triggers and Long-Term Control

NIH asthma researcher Stavros Garantziotis discusses the microbiome, environmental triggers, and long-term NHALES follow-up in North Carolina.

Oct 16, 2026

Pulmonology·NIH

Human lung organoids model antiviral immunity in respiratory disease

NIH-funded lung organoids preserved resident immune cells, mounted SARS-CoV-2 responses, and offered a new platform for vaccine and…

Oct 16, 2026

Pulmonology

Trials, guidelines and clinical evidence across Pulmonology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.