Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

SPOP-Mutant Prostate Cancer Shows Wnt and Replication Stress Signatures

Molecular stratification of SPOP-mutant prostate cancer links Wnt signaling and replication stress signatures across diverse patient populations.

By Dr. Revathy Mohan V.R., MBBS · Oct 21, 2026 · 4 min read

Oncology·Cancer Cell

Dietary alpha-ketoglutarate and lung adenocarcinoma growth studied by sex

A Cell Press study examines how dietary alpha-ketoglutarate may alter lung adenocarcinoma growth and epigenetic remodeling in a…

Oct 21, 2026

Oncology·Cancer Cell

RNA Modification Biomarkers Gain Attention in Disease Diagnosis and Prognosis

A 2025 review examines RNA modification biomarkers, machine learning methods, and the clinical barriers to diagnosis and prognosis…

Oct 21, 2026

Oncology·Cancer Cell

Multiple Myeloma Genomics Links Germline Risk to Clonal Evolution

A genomic framework for multiple myeloma links inherited susceptibility, founding lesions, and treatment-driven clonal evolution to risk stratification.

Oct 21, 2026

Oncology·Nat Immunol

PPARδ Activity Shapes Immunotherapy Response in Resistant Tumors

Compartment-specific PPARδ activity alters cancer and immune cell fitness, boosting CD8+ T-cell function and immunotherapy response in resistant…

Oct 21, 2026

Oncology·Nat Immunol

Oklahoma oncology faculty search targets metabolism, immunology and epigenetics

University of Oklahoma Health Sciences Center opens an oncology science faculty search with 5-year start-up support across cancer…

Oct 21, 2026

Oncology·Nat Immunol

CAR macrophage-neutrophil hybrids show anti-tumor activity in solid tumors

Engineered CAR macrophage-neutrophil hybrids delivered anti-tumor effects in solid tumors, extending cell therapy beyond conventional T-cell approaches.

Oct 21, 2026

Oncology·Nat Immunol

CD8+ T cells kill tumors by proxy in intratumoral activation study

Intratumoral activation allowed virus-specific memory CD8+ T cells to eradicate tumors without direct antigen recognition, pointing to proxy…

Oct 21, 2026

Oncology·Br J Cancer

Neoantigen Vaccine Feasibility Trial in Ovarian Cancer Shows Safety Focus

A phase 1 ovarian cancer trial tested personalized neoantigen vaccine feasibility and safety with delayed anti-PD-1 after platinum…

Oct 21, 2026

Oncology·Br J Cancer

Glioma Genomic Evolution Diverges in Astrocytomas and Oligodendrogliomas

Longitudinal sequencing of 183 IDH-mutant gliomas found distinct genomic routes of progression in astrocytomas and oligodendrogliomas after treatment.

Oct 21, 2026

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.