Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

Oncology trial design puts equipoise under ethical strain

A clinical ethics review examines how adaptive, seamless, and master-protocol oncology trials complicate traditional equipoise in phase III research.

Multi-omics and spatial analysis suggest glioblastoma organoids grown in microgravity better model advanced disease after long-term spaceflight.

Nuclear Golgin-45 acts as a transcription factor in lung cancer, reversing secretory programs and exposing a new layer…

A BMJ rapid response warns that the proposed 1 mm breast cancer margin threshold may not apply to…

NHS-Galleri randomised trial found no reduction in stage III or IV cancer incidence after annual testing, despite fewer…

Investigators explain why the NHS-Galleri screening trial uses late-stage cancer incidence and why a randomized multicancer liquid biopsy…

CDC state-level mortality data show wide variation in female breast cancer death rates in 2024, with DC highest…

A review of theragenerative nanomaterials examines how smart platforms may combine cancer treatment, tissue repair, and real-time diagnostics.

Verastem’s phase 1/2 trial is testing VS-7375 alone and in combinations for KRAS G12D-mutated solid tumors, including pancreatic,…

A Frontiers review says hyperbaric oxygen has not accelerated cancer in published human studies and may enhance radiation…

Oncology

Therapeutics, diagnostics and evidence shaping cancer care.

In Brief The 5-minute rounds