Neurology

From stroke to neurodegeneration — the science and its clinical impact.

Pregnancy Outcomes in MOGAD Show Lower Relapse Activity During Gestation

An updated systematic review found pregnancy often coincided with lower relapse activity in MOGAD, while postpartum risk remained variable across studies.

By Dr. A. Manasa, MBBS · Oct 23, 2026 · 5 min read

Neurology·Front Immunol

Optogenetics Review Examines Precision Neuromodulation in Neurodegeneration

A Frontiers review explores how optogenetics maps neural circuits and may guide precision neuromodulation strategies in neurodegenerative disease.

Oct 23, 2026

Neurology·Sci Transl Med

VG-3927/SAR448851 TREM2 Agonist Advances in Alzheimer’s Research

Preclinical and first-in-human work on oral TREM2 agonist VG-3927/SAR448851 explores a microglial strategy for Alzheimer’s disease.

Oct 23, 2026

Neurology·Becker H

Tissue-adhesive hydrogel optical fiber enables peripheral optogenetic neuromodulation

A tissue-adhesive hydrogel optical fiber delivered stable pancreatic optogenetic stimulation and improved glycemic control in diabetic mice.

Oct 23, 2026

Neurology·JNCI

Alcohol and dementia study in UK records to test subtype risk

UK electronic health records will test whether alcohol use raises dementia risk by subtype and worsens outcomes after…

Oct 23, 2026

Neurology·JCI

Purine metabolism disruption linked to Alzheimer’s cognitive decline

Purine metabolite changes tracked with amyloid burden, neuroinflammation, and cognitive decline in Alzheimer’s disease, while allantoin altered pathology…

Oct 23, 2026

Neurology·Nature

Nrf2-HO-1 activation rises after decompression in lumbar spinal stenosis model

Rat study links early Nrf2/HO-1 activation after decompression to reduced oxidative injury in lumbar spinal stenosis-related cauda equina…

Oct 23, 2026

Neurology·Nature

Stroke Alerts Gain AI Risk Stratification With Multimodal Prediction Model

A multimodal AI model using notes, EHR data, and time-series features predicted acute intracranial vascular events at stroke…

Oct 23, 2026

Neurology·ScienceDaily

Fish Oil Failed to Protect Memory in Two-Year Alzheimer’s Trial

A two-year trial in older adults at risk for Alzheimer’s found fish oil raised brain DHA but did…

Oct 23, 2026

Neurology·Becker H

Multiple sclerosis relapse detection rules perform well in Saudi EHR study

Rule-based EHR algorithms identified multiple sclerosis relapses with high sensitivity in a Saudi cohort, though specificity and PPV…

Oct 23, 2026

Neurology

From stroke to neurodegeneration — the science and its clinical impact.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.