Hematology

Trials, guidelines and clinical evidence across Hematology.

APLC 2025 consensus on MRD in adult acute lymphoblastic leukemia

APLC 2025 consensus recommendations address how measurable residual disease should be assessed and managed in adults with acute lymphoblastic leukemia.

By Dr. Revathy Mohan V.R., MBBS · Nov 2, 2026 · 5 min read

Hematology·STAT

IRF8 loss drives inflammatory bone marrow remodeling in CML

IRF8 suppression reshapes the leukemic marrow niche in chronic-phase CML, fueling neutrophil expansion, stromal activation, and early fibrosis.

Nov 2, 2026

Hematology·Blood

Sickle Cell Gene Therapy Implementation Guidance Takes Center Stage at ASH

ASH consensus recommendations address how gene therapy for sickle cell disease should move from trial setting to real-world…

Nov 2, 2026

Hematology·Blood

MRD-Guided Ibrutinib Plus Venetoclax Improves QoL in CLL

HOVON 141/VISION trial results link MRD-guided ibrutinib plus venetoclax with better quality of life in relapsed/refractory CLL.

Nov 2, 2026

Hematology·Blood

ASH and HHS Registry Roundtable Targets Sickle Cell Care Gaps

ASH and HHS convened registry leaders around sickle cell disease care, focusing on collaboration, data harmonization, and long-term…

Nov 2, 2026

Hematology·ClinicalTrials

Anxiety and Depression in Hematologic Malignancies Study Tracks Treatment Failure

Prospective cohort study will assess whether baseline anxiety and depression predict treatment failure, survival, and response in hematologic…

Nov 1, 2026

Hematology·HHS

HHS expands sickle cell care with seven regional hubs nationwide

HHS and HRSA are expanding sickle cell care through seven regional hubs to improve access, care coordination, and…

Nov 1, 2026

Hematology·Blood

Reporter Strategy Identifies Nonmigratory Hematopoietic Stem Cells in Bone Marrow

A new reporter strategy identifies a subset of nonmigratory hematopoietic stem cells within a dynamic bone marrow niche,…

Nov 1, 2026

Hematology·Front Immunol

Immune Remission Framework Proposed for Immune Thrombocytopenia

A Frontiers in Immunology perspective proposes immune remission in ITP as a research framework beyond platelet recovery, with…

Nov 1, 2026

Hematology·Brain

X-Rayed Rabbit Hemolysin Study Points to Nucleic Acid Rescue

An older experimental study in rabbits examined whether nucleic acid derivatives could restore hemolysin formation after X-ray exposure.

Oct 31, 2026

Hematology

Trials, guidelines and clinical evidence across Hematology.

In Brief The 5-minute rounds

New hypertension guideline lowers the treatment threshold to 130/80 mm Hg.
Phase 3 GLP-1 trial reports a 20% cut in major adverse cardiac events.
FDA clears a next-generation CAR-T therapy for relapsed lymphoma.
Meta-analysis links early mobilisation to shorter ICU length of stay.
Rapid guidance broadens empiric antibiotics for suspected sepsis.